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Loss of beta-III spectrin leads to Purkinje cell dysfunction recapitulating the behavior and neuropathology of spinocerebellar ataxia type 5 in humans.

• Emma Margaret Perkins, Yvonne L. Clarkson, +10 authors Mandy Jackson
• The Journal of neuroscience : the official…
• 2010

Mutations in SPTBN2, the gene encoding beta-III spectrin, cause spinocerebellar ataxia type 5 in humans (SCA5), a neurodegenerative disorder resulting in loss of motor coordination. How these… (More)

The effect of short-term fasting and a single meal on protein synthesis and oxygen consumption in cod, Gadus morhua

• Alastair R. Lyndon, Dominic F. Houlihan, Steven J Hall
• Journal of Comparative Physiology B
• 1992

Rates of protein synthesis and oxygen consumption ( $$\dot M$$ O2) in cod were compared in both fasted and refed animals. During a 14-day fast both protein synthesis and respiration rates fell to… (More)

Efficacy of in-feed probiotics against Aeromonas bestiarum and Ichthyophthirius multifiliis skin infections in rainbow trout (Oncorhynchus mykiss, Walbaum).

• N Pieters, Jason Brunt, Brian Austin, Alastair R. Lyndon
• Journal of applied microbiology
• 2008

AIMS The aim of this study was to assess the efficacy of in-feed probiotics as a preventive measure against skin infections caused by Aeromonas bestiarum and Ichthyophthirius multifiliis (Ich) in… (More)

Gill protein turnover: costs of adaptation.

• Alastair R. Lyndon, Dominic F. Houlihan
• Comparative biochemistry and physiology. Part A…
• 1998

Measurements of gill protein synthesis, and hence turnover, were greatly facilitated over the last decade by the application of "flooding dose" methodology to non-mammalian species. Numerous studies… (More)

Changes in tissue and plasma free amino acid concentrations after feeding in Atlantic cod

• Alastair R. Lyndon, Ian C. Davidson, Dominic F. Houlihan
• Fish Physiology and Biochemistry
• 1993

Atlantic cod, Gadus morhua, were maintained on a diet of sandeel and after a 6-day fast were refed a single meal. Concentrations of free amino acids (AAs) were measured in hepatic portal and cardiac… (More)

Antigenic and cross-protection studies of biotype 1 and biotype 2 isolates of Yersinia ruckeri in rainbow trout, Oncorhynchus mykiss (Walbaum).

• Jasmine Tinsley, Alastair R. Lyndon, Brian Austin
• Journal of applied microbiology
• 2011

AIMS The study investigated antigen characteristics of biotype (bt) 1 and bt 2 isolates of Yersinia ruckeri. METHODS AND RESULTS The cell surface characteristics of Y. ruckeri were compared for… (More)

β-III spectrin underpins ankyrin R function in Purkinje cell dendritic trees: protein complex critical for sodium channel activity is impaired by SCA5-associated mutations

• Yvonne L. Clarkson, Emma Margaret Perkins, Callum J. Cairncross, Alastair R. Lyndon, Paul A. Skehel, Mandy Jackson
• Human molecular genetics
• 2014

Beta III spectrin is present throughout the elaborate dendritic tree of cerebellar Purkinje cells and is required for normal neuronal morphology and cell survival. Spinocerebellar ataxia type 5… (More)

Protein synthesis in a fish heart: responses to increased power output.

• Dominic F. Houlihan, Claudio Agnisola, Alastair R. Lyndon, Clint Gray, Niall M. Hamilton
• The Journal of experimental biology
• 1988

The effects of exercise on the rates of protein synthesis in the chambers of the trout heart were investigated in vitro and in vivo. An in vitro rainbow trout heart preparation was developed which… (More)

Beta-III spectrin mutation L253P associated with spinocerebellar ataxia type 5 interferes with binding to Arp1 and protein trafficking from the Golgi.

• Yvonne L. Clarkson, Trudi Gillespie, Emma Margaret Perkins, Alastair R. Lyndon, Mandy Jackson
• Human molecular genetics
• 2010

Spinocerebellar ataxia type 5 (SCA5) is an autosomal dominant neurodegenerative disorder caused by mutations in beta-III spectrin. A mouse lacking full-length beta-III spectrin has a phenotype… (More)

Effect of incubation temperature on carbohydrate digestion in important teleosts for aquaculture

• Eustratios S. Papoutsoglou, Alastair R. Lyndon
• 2005

The activity and capacity (activity tissue weight) of digestive carbohydrases (total carbohydrase, aglucosidase, a-amylase) was examined in vitro under a range of (more realistic) incubation… (More)

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