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Multiple sclerosis is the prototype inflammatory autoimmune disorder of the central nervous system and, with a lifetime risk of one in 400, potentially the most common cause of neurologicalContinue Reading
  • Alastair Compston, Alasdair Coles
  • Medicine
  • The Lancet
  • 2008 (First Publication: 31 October 2008)
  • Multiple sclerosis is primarily an inflammatory disorder of the brain and spinal cord in which focal lymphocytic infiltration leads to damage of myelin and axons. Initially, inflammation is transientContinue Reading
  • Sybil R.L. Stacpoole, Sonia Spitzer, +4 authors Robin J. M. Franklin
  • Biology, Medicine
  • Stem cell reports
  • 2013 (First Publication: 31 October 2013)
  • We have established and efficient system to specify NG2/PDGF-Rα/OLIG2+ oligodendrocyte precursor cells (OPCs) from human embryonic stem cells (hESCs) at low, physiological (3%) oxygen levels. ThisContinue Reading
  • John D Rioux, Philippe Goyette, +25 authors Stephen L. Hauser
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2009 (First Publication: 3 November 2009)
  • The human MHC represents the strongest susceptibility locus for autoimmune diseases. However, the identification of the true predisposing gene(s) has been handicapped by the strong linkageContinue Reading