Alasdair Simpson

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1. Experiments were performed on chloralose-urethane anaesthetized rats to determine the involvement of extrinsic gastric autonomic nerves in reflex facilitation and inhibition of gastric motility when mechanical nociceptive stimulation was delivered to either hind paw or abdominal skin, respectively. 2. After bilaterally sectioning the splanchnic nerves in(More)
Ca(2+)-stimulated adenylyl cyclases (AC) are known to play important roles in neurons but have not previously been reported in the heart. Here we present the first evidence for selective expression of Ca(2+)-stimulated AC in the sino-atrial node (SAN) but not in ventricular muscle of the guinea-pig heart. The AC1 isoform of Ca(2+)-stimulated AC was shown to(More)
In rats anesthetized with pentobarbital or a mixture of urethane and chloralose, horseradish peroxidase (HRP) was injected into the intermediolateral column of the spinal cord (Th7 and Th9) or the posterior pituitary lobe. HRP positive cells were found mainly in the dorsomedial part of the paraventricular nuclease (PVN) of the spinal injected animals. These(More)
Whether secretion of gastric acid (GAS) is in response to peripheral and/or central administration of chemical or electrical stimuli can be differentiated by vagotomy. GAS has been shown to be controlled by specific lateral hypothalamic (LHA) neurons. Application of 2-deoxy-D-glucose (2-DG) or insulin to the LHA by microinjection or iontophoresis has(More)
Gastrin related peptides (PG) affected neurons in the lateral hypothalamus (LHA) differently in food deprived than in non-deprived rats. Electroosmosis and intravenous (IV) results agreed. Gastric acid secretion was also measured. Neural responses to PG were: transiently increased discharge rate followed by desensitization occurred equally in deprived and(More)
Electroosmotic applications of 2-deoxy-D-glucose (2-DG) were made in the lateral hypothalamus (LHA). Changes in LHA unit activity and concomitant gastric acid secretion were then observed 2-DG responsive neurons tended to form two clusters in the LHA. Electroosmotic application induced four patterns of activity change in different LHA neurons. Gastric acid(More)
A cooling thermode is described that can be used to reversibly lesion deep structures with minimal penetration damage. Construction, associated equipment, and use of this thermode are simpler and less expensive, and it can be made smaller in size, than previously described thermodes. The user has a choice of a simple, inexpensive control arrangement that is(More)
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