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People can consciously re-experience past events and pre-experience possible future events. This fMRI study examined the neural regions mediating the construction and elaboration of past and future events. Participants were cued with a noun for 20s and instructed to construct a past or future event within a specified time period (week, year, 5-20 years).(More)
Episodic memory enables individuals to recollect past events as well as imagine possible future scenarios. Although the episodic specificity of past events declines as people grow older, it is unknown whether the same is true for future events. In an adapted version of the Autobiographical Interview, young and older participants generated past and future(More)
The myelin-associated glycoprotein (MAG) is an intrinsic membrane protein that is specific for myelinating cells. MAG has been proposed to function in the PNS as an adhesion molecule involved in Schwann cell-axon contact and maintenance of cytoplasmic channels within the myelin sheath. In this report we show that the microfilament components, F-actin and(More)
Human behavioral studies demonstrate that healthy aging is often accompanied by increases in memory distortions or errors. Here we used event-related fMRI to examine the neural basis of age-related memory distortions. We used the memory conjunction error paradigm, a laboratory procedure known to elicit high levels of memory errors. For older adults, right(More)
Stress can exert long-lasting changes on the brain that contribute to vulnerability to mental illness, yet mechanisms underlying this long-term vulnerability are not well understood. We hypothesized that stress may alter the production of oligodendrocytes in the adult brain, providing a cellular and structural basis for stress-related disorders. We found(More)
The frequency with which diethylstilbestrol induces neoplastic transformation and somatic mutation was measured concomitantly in Syrian hamster embryo cells. While diethylstilbestrol was as active as benzo[a]pyrene in inducing transformation, it failed to induce mutations at two conventionally studied loci. These results suggest that diethylstilbestrol may(More)
(2011). A neural mechanism mediating the impact of episodic prospection on farsighted decisions. overcome their current desires to anticipate two distinct future needs and plan for them appropriately. The future is where we will live the rest of our lives, so we devote a lot of the present to planning for it. Psychological research has provided insights(More)
Fibrinogen fragment D, which is heterogeneous, has several important biological functions. Human fibrinogen fragments D94 (molecular weight, 94,000), D78 (78,000), and E (52,000) were purified. Fragments D78 and D94 but not purified fibrinogen or fragment E specifically caused disorganization of bovine aortic endothelial cells cultured as monolayers. Within(More)
Introduction This digital learning object was developed for use primarily by faculty and students in the context of higher education, but it may also be a useful resource for individuals in professional organizations. Mentoring is a learning process where helpful, personal, and reciprocal relationships are built while focusing on achievement; emotional(More)
(2007). Remembering the past and imagining the future: Common and distinct neural substrates during event construction and elaboration. Implicit and explicit memory for new associations in normal and amnesic subjects. for the hippocampus in encoding simulations of future events. (1996). Conscious recollection and the human hippocampal formation: Evidence(More)