Alan T . Hirsch

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CONTEXT Peripheral arterial disease (PAD) is a manifestation of systemic atherosclerosis that is common and is associated with an increased risk of death and ischemic events, yet may be underdiagnosed in primary care practice. OBJECTIVE To assess the feasibility of detecting PAD in primary care clinics, patient and physician awareness of PAD, and(More)
CONTEXT Prediction models to identify healthy individuals at high risk of cardiovascular disease have limited accuracy. A low ankle brachial index (ABI) is an indicator of atherosclerosis and has the potential to improve prediction. OBJECTIVE To determine if the ABI provides information on the risk of cardiovascular events and mortality independently of(More)
CONTEXT Few data document current cardiovascular (CV) event rates in stable patients with atherothrombosis in a community setting. Differential event rates for patients with documented coronary artery disease (CAD), cerebrovascular disease (CVD), or peripheral arterial disease (PAD) or those at risk of these diseases have not been previously evaluated in a(More)
CONTEXT Atherothrombosis is the leading cause of cardiovascular morbidity and mortality around the globe. To date, no single international database has characterized the atherosclerosis risk factor profile or treatment intensity of individuals with atherothrombosis. OBJECTIVE To determine whether atherosclerosis risk factor prevalence and treatment would(More)
We compared the activity and physiologic effects of cardiac angiotensin converting enzyme (ACE) using isovolumic hearts from male Wistar rats with left ventricular hypertrophy due to chronic experimental aortic stenosis and from control rats. In response to the infusion of 3.5 X 10(-8) M angiotensin I in the isolated buffer perfused beating hearts, the(More)
Management of Patients with Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic) A Collaborative Report from the American Associations for Vascular Surgery/Society for Vascular Surgery,* Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology,(More)
2011 WRITING GROUP MEMBERS* Thom W. Rooke, MD, FACC, Chair†; Alan T. Hirsch, MD, FACC, Vice Chair*; Sanjay Misra, MD, Vice Chair*‡; Anton N. Sidawy, MD, MPH, FACS, Vice Chair§; Joshua A. Beckman, MD, FACC, FAHA* ; Laura K. Findeiss, MD‡; Jafar Golzarian, MD†; Heather L. Gornik, MD, FACC, FAHA*†; Jonathan L. Halperin, MD, FACC, FAHA*¶; Michael R. Jaff, DO,(More)