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The identification of orthologs-genes pairs descended from a common ancestor through speciation, rather than duplication-has emerged as an essential component of many bioinformatics applications, ranging from the annotation of new genomes to experimental target prioritization. Yet, the development and application of orthology inference methods is hampered(More)
There is an increase use of ontology-driven approaches to support requirements engineering (RE) activities, such as elicitation, analysis, specification, validation and management of requirements. However, the RE community still lacks a comprehensive understanding of how ontologies are used in RE process. Thus, the main objective of this work is to(More)
Paracoccidioidomycosis is a fungal infection caused by Paracoccidioides brasiliensis. It is an endemic disease, representing a serious health problem in Latin American countries. This infection primarily affects the lungs and is acquired by inhalation of the fungus. It can spread to other organs and tissues, mainly the oral cavity affecting more adult men(More)
Requirements models can be used to describe what is expected from a software system. On the other hand, architectural models can describe the structure of a system in terms of its components and connectors. However, these models do not capture the rationale of the decisions made during architectural design. This knowledge is important throughout the(More)
  • Ig Bittencourt, Evandro Costa, Hyggo Almeida, Baldoino Fonseca, Guilherme Maia, Ivo Calado +1 other
  • 2007
Intelligent Tutoring Systems (ITS) are inherently complex, domain-oriented software systems which are frequently pointed out by researchers as suitable applications for the multi-agent approach. Developing and maintaining Multi-agent ITS are a hard task since it involves different stakeholders, with different expert and roles, such as developers, for(More)
The automated negotiation topic plays an important role in e-commerce research. However, despite considerable work on automated negotiation, few research efforts have aimed at software engineering facilities such a reuse and flexibility. To address this issue, we propose a novel computation environment for building agents with flexible negotiation(More)
Understanding the molecular mechanisms of oral carcinogenesis will yield important advances in diagnostics, prognostics, effective treatment, and outcome of oral cancer. Hence, in this study we have investigated the proteomic and peptidomic profiles by combining an orthotopic murine model of oral squamous cell carcinoma (OSCC), mass spectrometry-based(More)