Alan Seefeldt

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The increasing prevalence of multidrug-resistant pathogenic bacteria is making current antibiotics obsolete. Proline-rich antimicrobial peptides (PrAMPs) display potent activity against Gram-negative bacteria and thus represent an avenue for antibiotic development. PrAMPs from the oncocin family interact with the ribosome to inhibit translation, but their(More)
The effects of gonadectomy on the secretion of prolactin, LH, TSH, and thyroxine were investigated. Blood serum hormone concentrations were analysed before and at 20, 120, and 180min after a single iv TRH injection in each of eight healthy intact and castrated male beagle dogs before (control) and after 4-week treatment with the dopamine-2 receptor agonist(More)
This case report describes the clinical course, the diagnostic and therapeutic management as well as histopathological findings in a case of foetal retention for about 5 months in a 5-year-old Boxer. Clinical symptoms included mucosanguinous vaginal discharge and a firm ovoid mass of about duck egg size palpable in mid abdomen. Sonographic examination was(More)
Proline-rich antimicrobial peptides (PrAMPs) produced as part of the innate immune response of animals, insects and plants represent a vast, untapped resource for the treatment of multidrug-resistant bacterial infections. PrAMPs such as oncocin or bactenecin-7 (Bac7) interact with the bacterial ribosome to inhibit translation, but their supposed specificity(More)
Covering: up to 2017The innate immune system employs a broad array of antimicrobial peptides (AMPs) to attack invading microorganisms. While most AMPs act by permeabilizing the bacterial membrane, specific subclasses of AMPs have been identified that pass through membranes and inhibit bacterial growth by targeting fundamental intracellular processes. One(More)
This thesis proposes a method for the single-sensor enhancement of speech that has been corrupted by additive broadband noise. The method is based on a technique known as Sinusoidal Analysis-Synthesis (SAS) and involves two steps. First, sinusoidal tracks relevant to the speech alone are extracted from the short-time spectrum of the corrupted speech.(More)
Concentrations of prolactin (PRL), LH, testosterone (T), TSH and thyroxine (T(4)) were determined before and at 20, 120 and 180 min after a single iv injection of thyrotropin-releasing hormone (TRH) in eight Beagles, eight Fox Terriers, six Labrador Retrievers and five Great Danes that were normospermic. Mean basal PRL concentrations were lower in the Fox(More)
The field of Digital Signal Processing grew out of the flexibility afforded by the use of digital computers in implementing signal processing algorithms and systems. It has since broadened into the use of a variety of both digital and analog technologies, spanning a broad range of applications, bandwidths, and realizations. The Digital Signal Processing(More)
In all living cells ribosomes are responsible for the translation of genetic information into the corresponding protein sequence. This central position does not only make them a valuable target for antibiotics but also offers great possibilities to regulate gene expression. This article addresses two distinct mechanisms of ribosomal activity regulation: via(More)
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