Alan R Aitkenhead

Learn More
Morphine 0.125 mg kg-1 was administered i.v. to 11 normal subjects and nine patients with chronic renal failure requiring regular haemodialysis. Plasma morphine concentrations were measured using high pressure liquid chromatography (HPLC). Although there was considerable individual variation in both groups, mean plasma concentrations of morphine were(More)
In a randomized, prospective study of patients undergoing large bowel anastomosis, 47 patients received subarachnoid block and light general anaesthesia, and 51 received conventional general anaesthesia with intermittent positive pressure ventilation. Anastomotic dehiscence occurred in 17.0% of the spinal group and in 17.6% of patients anaesthetized by the(More)
The anaesthetized patient is at risk of complications resulting from the actions, or inaction, of the anaesthetist, from the actions of the surgeon, and from failure or malfunction of anaesthetic equipment. The state of anaesthesia may be considered to be intrinsically unsafe. Patients are subjected to administration of drugs which have side-effects,(More)
Tussometry is a new non-invasive method of assessing laryngeal function by analysing the airflow waveform produced by a voluntary cough. Ten healthy male volunteers performed five (n = 6) or six (n = 4) voluntary cough manoeuvres at varying lung volumes from total lung capacity to functional residual capacity. During each manoeuvre, airflow (litre min-1)(More)
We studied 10 patients undergoing laparoscopic cholecystectomy (group 1) and five control patients (group 2). We measured heart rate, arterial pressure, right atrial pressure (RAP), cardiac index (CI), systemic vascular resistance index (SVRI), intrathoracic pressure (ITP), plasma osmolality, adrenaline, noradrenaline and arginine vasopressin (aVP)(More)
We aimed to validate the mathematical validity and accuracy of the respiratory components of the Nottingham Physiology Simulator (NPS), a computer simulation of physiological models. Subsequently, we aimed to assess the accuracy of the NPS in predicting the effects of a change in mechanical ventilation on patient arterial blood-gas tensions. The NPS was(More)
A simple method for the simultaneous determination of morphine and its pharmacologically active metabolite morphine-6-glucuronide in 0.5 ml human plasma is described. It is based on the method of Svensson [J. Chromatogr., 230 (1982) 427 and 375 (1986) 174], but uses only one solid-phase extraction cartridge prior to chromatography and only a 20-microliter(More)
The aim of this study was to examine the performance of anaesthetists while managing simulated anaesthetic crises and to see whether their performance was improved by reviewing their own performances recorded on videotape. Thirty-two subjects from four hospitals were allocated randomly to one of two groups, with each subject completing five simulations in a(More)
In a double-blind, randomized study, we have examined the influence of positive therapeutic suggestions, presented to anaesthetized patients undergoing total abdominal hysterectomy, on postoperative morbidity and duration of hospital stay. Seventy-five patients were allocated randomly to be exposed to one of three tapes containing positive therapeutic(More)
BACKGROUND AND OBJECTIVE Intrathecal opioids are now used routinely in the UK for intra- and postoperative analgesia. The opioids of choice have altered over recent years and the dosage regimens used can vary between institutions. Concerns over safety have been reduced probably because much lower doses of opioids are now being used. This survey explored the(More)