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In a randomized, prospective study of patients undergoing large bowel anastomosis, 47 patients received subarachnoid block and light general anaesthesia, and 51 received conventional general anaesthesia with intermittent positive pressure ventilation. Anastomotic dehiscence occurred in 17.0% of the spinal group and in 17.6% of patients anaesthetized by the(More)
The anaesthetized patient is at risk of complications resulting from the actions, or inaction, of the anaesthetist, from the actions of the surgeon, and from failure or malfunction of anaesthetic equipment. The state of anaesthesia may be considered to be intrinsically unsafe. Patients are subjected to administration of drugs which have side-effects,(More)
One thousand patients who were anaesthetised between February and April 1990 at University Hospital, Nottingham were interviewed between 20 and 36 hours after their operation. Patients under 16 years of age, those who had undergone obstetric or intracranial surgery, those who were unable to communicate and patients who were discharged from hospital before(More)
We studied 10 patients undergoing laparoscopic cholecystectomy (group 1) and five control patients (group 2). We measured heart rate, arterial pressure, right atrial pressure (RAP), cardiac index (CI), systemic vascular resistance index (SVRI), intrathoracic pressure (ITP), plasma osmolality, adrenaline, noradrenaline and arginine vasopressin (aVP)(More)
Morphine 0.125 mg kg-1 was administered i.v. to 11 normal subjects and nine patients with chronic renal failure requiring regular haemodialysis. Plasma morphine concentrations were measured using high pressure liquid chromatography (HPLC). Although there was considerable individual variation in both groups, mean plasma concentrations of morphine were(More)
Tussometry is a new non-invasive method of assessing laryngeal function by analysing the airflow waveform produced by a voluntary cough. Ten healthy male volunteers performed five (n = 6) or six (n = 4) voluntary cough manoeuvres at varying lung volumes from total lung capacity to functional residual capacity. During each manoeuvre, airflow (litre min-1)(More)
BACKGROUND AND OBJECTIVE Intrathecal opioids are now used routinely in the UK for intra- and postoperative analgesia. The opioids of choice have altered over recent years and the dosage regimens used can vary between institutions. Concerns over safety have been reduced probably because much lower doses of opioids are now being used. This survey explored the(More)
Twelve patients presenting to an accident and emergency department in asystolic cardiac arrest were randomly allocated to treatment with endotracheal adrenaline (five patients) or peripheral intravenous adrenaline (seven patients). Femoral-artery blood samples were taken for assay of adrenaline and noradrenaline. After intravenous adrenaline there was a(More)
Clinicians worldwide are required to maintain an increasing workload with limited or contracting resources. The following guidelines have been developed by an independent international task force on safety in the intensive care unit in order to describe safety standards for tertiary or referral intensive care units (ICUs). These ICUs should be specially(More)