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The anaesthetized patient is at risk of complications resulting from the actions, or inaction, of the anaesthetist, from the actions of the surgeon, and from failure or malfunction of anaesthetic equipment. The state of anaesthesia may be considered to be intrinsically unsafe. Patients are subjected to administration of drugs which have side-effects,(More)
One thousand patients who were anaesthetised between February and April 1990 at University Hospital, Nottingham were interviewed between 20 and 36 hours after their operation. Patients under 16 years of age, those who had undergone obstetric or intracranial surgery, those who were unable to communicate and patients who were discharged from hospital before(More)
Tussometry is a new non-invasive method of assessing laryngeal function by analysing the airflow waveform produced by a voluntary cough. Ten healthy male volunteers performed five (n = 6) or six (n = 4) voluntary cough manoeuvres at varying lung volumes from total lung capacity to functional residual capacity. During each manoeuvre, airflow (litre min-1)(More)
Morphine 0.125 mg kg-1 was administered i.v. to 11 normal subjects and nine patients with chronic renal failure requiring regular haemodialysis. Plasma morphine concentrations were measured using high pressure liquid chromatography (HPLC). Although there was considerable individual variation in both groups, mean plasma concentrations of morphine were(More)
UNLABELLED We used the Nottingham Physiology Simulator to examine the onset and course of hypoxemia during apnea after pulmonary denitrogenation. The following factors, as possible determinants of the hypoxemia profile, were varied to examine their effect: functional residual capacity, oxygen consumption, respiratory quotient, hemoglobin concentration,(More)
Many factors influence the outcome after surgery of the bowel. However, care in anaesthetic and postoperative management may help to reduce the frequency of complications. Such care can be directed at maintenance of or improvement in oxygen delivery to the bowel by the avoidance of hypoxia, hypocapnia and hypovolaemia, and by careful selection of drugs and(More)
UNLABELLED Using an original, validated, high-fidelity model of pulmonary physiology, we compared the arterial to end-tidal CO(2) gradient divided by the arterial CO(2) tension (Pa-E'CO(2)/PaCO(2)) with alveolar dead space expressed as a fraction of alveolar tidal volume, calculated in the conventional manner using Fowler's technique and the Bohr equation:(More)
Fifty ASA 1 or 2 patients scheduled to undergo major gynaecological surgery were allocated randomly to one of two groups. All patients received a standard anaesthetic regimen. Patients in group 1 received droperidol 1.25 mg given intravenously 20 min prior to the end of surgery and a patient-controlled analgesia infusion containing morphine 1 mg.ml-1 and(More)