Alan Purvis

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The normal plasma protein serum amyloid P component (SAP) binds to fibrils in all types of amyloid deposits, and contributes to the pathogenesis of amyloidosis. In order to intervene in this process we have developed a drug, R-1-[6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl]pyrrolidine-2-carboxylic acid, that is a competitive inhibitor of SAP binding to(More)
This paper introduces Deluge, a second generation FPGA based key search system that specifically targets stream ciphers. The economically feasible implementation described is in dramatic contrast to other attack techniques and lends weight to the argument that brute-force attacks are underestimated in the security evaluation of cipher designs. Moreover with(More)
An application of Iterated Function Systems to the problem of automatic generation of two-dimensional shape representation is presented. A definition of an Iterated Function System is given, and the properties that make it suitable for shape representation are described. Details of programs implementing shape coding and rendering are provided together with(More)
At the 1990 ICMC, this research group presented a paper on a multi-transputer based system [Bailey et al., 1990] and demonstrated a prototype module consisting of 16 transputers on a single card. During the intervening period, ten of these cards have been developed into an operational audio processing network, using 160 x T800 floating-point transputers,(More)
The polymerization of laminins into a cell-associated network is a key process in basement membrane assembly. Network formation is mediated by the homologous short arm tips of the laminin heterotrimer, each consisting of a globular laminin N-terminal (LN) domain followed by a tandem of laminin-type epidermal growth factor-like (LEa) domains. How the short(More)
Under physiological conditions, the pentameric human plasma protein serum amyloid P component (SAP) binds hexanoyl bis(D-proline) (R-1-{6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl}pyrrolidine-2-carboxylic acid; CPHPC) through its D-proline head groups in a calcium-dependent interaction. Cooperative effects in binding lead to a substantial enhancement of(More)