Alan Perkins

Learn More
Recombinant human erythropoietin (rHuEPO) is an effective treatment for anemia in patients with cancer, and recent studies show that over two-thirds of patients can be expected to respond with a large increase (>2 g/dl) in hemoglobin concentration. However, it would be helpful to identify likely responders and nonresponders before initiating treatment.(More)
The stability of an immunogen against enzymatic degradation is considered an important factor for the design of synthetic vaccines. For our studies, we have selected an epitope from the tandem-repeat unit of the high-molecular-weight MUC2 mucin glycoprotein, which can be underglycosylated in case of colon cancer. In this study, we prepared a MUC2 peptide(More)
Physical techniques have always had a key role in medicine, and the second half of the 20th century in particular saw a revolution in medical diagnostic techniques with the development of key imaging instruments: x-ray imaging and emission tomography (nuclear imaging and PET), MRI, and ultrasound. These techniques use the full width of the electromagnetic(More)
Tumours identified clinically or by external imaging frequently require surgical treatment. The effectiveness of such treatment is invariably dependent upon the complete excision of all tumour tissue. Microscopic and occult disease not readily seen by the surgeon may remain in situ, ultimately leading to the patient's demise. Despite the use of(More)
A business rule Vejines or constrains some aspeci of ihe business. I t is iniended to assert business siructure, or to control or injluence the behavior of ihe business." -The IBM GUIDE Organization. By capturing their business rules as meta-daia, enterprises consisienily deliver effective strategic information -on demand, to the right people, in the right(More)
BACKGROUND/AIMS A number of subjective methods have been used to quantify the extent of the cutaneous delayed-type hypersensitivity (DTH) reaction. However, because of their subjective nature, significant differences in measurements may be seen between individual observers or laboratories unless thorough training is given to each observer. METHODS(More)
Extensions of Einstein gravity with higher-order derivative terms arise in string theory and other effective theories, as well as being of interest in their own right. In this Letter we study static black-hole solutions in the example of Einstein gravity with additional quadratic curvature terms. A Lichnerowicz-type theorem simplifies the analysis by(More)