Alan M. Smith

Publications63
h-index20
Citations1,391
Highly Influential Citations30
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Chitosan
TLDR
The totality of the meaningful information (including key unpublished data) supporting the development of chitosan-adjuvanted vaccines is summarized.
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Molecular flexibility of citrus pectins by combined sedimentation and viscosity analysis
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Macromolecular conformation of chitosan in dilute solution: A new global hydrodynamic approach
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PecSys: in situ gelling system for optimised nasal drug delivery
TLDR
The lead product using PS is a fentanyl nasal spray formulation (NasalFent®), which has successfully met the primary objective in a pivotal Phase III clinical study and is scheduled for regulatory filings in the first half of 2009.
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Transdermal Delivery of Interferon Alpha-2B using Microporation and Iontophoresis in Hairless Rats
TLDR
Iontophoresis enhanced delivery through microporated skin in hairless rats resulted in a two-fold increase in the dose delivered in the hairless rat, and in vivo delivery of IFNα2b was demonstrated throughmicropores created in the outer layer of the skin.
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Intranasal delivery of recombinant human growth hormone (somatropin) in sheep using chitosan-based powder formulations.
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Development of in vitro models to demonstrate the ability of PecSys®, an in situ nasal gelling technology, to reduce nasal run-off and drip
TLDR
In vivo, this enhancement of retention will provide optimum patient acceptability, modulate drug absorption and maximize the ability of drugs to be absorbed across the nasal mucosa and thus reduce variability in drug delivery.
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The effect of prolonged storage at different temperatures on the particle size distribution of tripolyphosphate (TPP)-chitosan nanoparticles
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The effect of different storage temperatures on the physical properties of pectin solutions and gels
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Riluzole: real-world evidence supports significant extension of median survival times in patients with amyotrophic lateral sclerosis
TLDR
Real-world evidence (RWE) from 10 clinical ALS databases indicates that riluzole therapy may afford much greater extension of survival, and improvements in median survival times of more than 19 months have been reported in the overall ALS patient population.
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