Alan M. O’Neill

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Trends and variations in global stratospheric temperatures are an integral part of the changes occurring in the Earth’s climate system. Data sets for analyzing long-term (a decade and more) changes in the stratospheric temperatures consist of radiosonde, satellite, lidar, and rocketsonde measurements; meteorological analyses based on radiosonde and/or(More)
Air-fluorescence detectors such as the High Resolution Fly’s Eye (HiRes) detector are very sensitive to upwardgoing, Earth-skimming ultra-high-energy electron-neutrino-induced showers. This is due to the relatively large interaction cross sections of these high-energy neutrinos and to the Landau-Pomeranchuk-Migdal (LPM) effect. The LPM effect causes a(More)
UNLABELLED As key components of innate immune defense, macrophages are essential in controlling bacterial pathogens, including group A Streptococcus(GAS). Despite this, only a limited number of studies have analyzed the recovery of GAS from within human neutrophils and macrophages. Here, we determined the intracellular fate of GAS in human macrophages by(More)
Infection with human immunodeficiency virus-1 (HIV-1) causes brain injury. Type I interferons (IFNα/β) are critical mediators of any anti-viral immune response and IFNβ has been implicated in the temporary control of lentiviral infection in the brain. Here we show that transgenic mice expressing HIV-1 envelope glycoprotein 120 in their central nervous(More)
RESUME We provide first results of work toward the evaluation of Envisat data using the Met Office (UK) Numerical Weather Prediction (NWP) System. The Envisat data to be evaluated is level 2 temperature, ozone and water vapour from MIPAS and GOMOS, and level 2 total column ozone data from SCIAMACHY. Initially, we focus on the evaluation of MIPAS and(More)
Volume 7, no. 2, doi:10.1128/mBio.00020-16, 2016. We inadvertently omitted to acknowledge the generosity of Joseph Ferretti for providing the M49 NZ131 strain and a mutant derivative lacking the SLO toxin (D. J. Savic, W. M. McShan, and J. J. Ferretti. 2002. Autonomous expression of the slo gene of the bicistronic nga-slo operon of Streptococcus pyogenes.(More)
Air-fluorescence detectors such as the High Resolution Fly’s Eye (HiRes) detector are very sensitive to upward-going, Earth-skimming ultrahigh energy electron-neutrino-induced showers. This is due to the relatively large interaction cross sections of these high-energy neutrinos and to the Landau-PomeranchukMigdal (LPM) effect. The LPM effect causes a(More)
A new retrieval scheme has been developed to produce height-resolved ozone profiles spanning the troposphere and stratosphere from measurements made by the Global Ozone Monitoring Experiment (GOME). Comparison of those profiles with ozone sonde data reveals good agreement throughout the troposphere and stratosphere, with significant improvement over(More)
[1] On 15 July 2004, the Ozone Monitoring Instrument (OMI) on board the EOS Aura mission was launched. One of OMI’s priorities is to continue the record of high spatial resolution ozone total column measurements provided by the various Total Ozone Mapping Spectrometer (TOMS) instruments since 1978. To this end, it is essential to estimate the errors(More)
RESUME The assimilation of MIPAS ozone and water vapour data into the Met Office’s Unified Model is discussed. The MIPAS dataset (which also includes temperature) is assimilated together with standard operational datasets. Evaluation of the ozone analyses, using selfconsistency tests and comparisons against independent data, indicates that they provide a(More)