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ChREBP regulates fructose-induced glucose production independently of insulin signaling.

• Moonjeong Kim, Sarah A. Krawczyk, +10 authors Mark A. Herman
• The Journal of clinical investigation
• 2016

Obese, insulin-resistant states are characterized by a paradoxical pathogenic condition in which the liver appears to be selectively insulin resistant. Specifically, insulin fails to suppress glucose… (More)

Intestinal, but not hepatic, ChREBP is required for fructose tolerance.

• Misung Kim, Inna I Astapova, +7 authors Mark A. Herman
• JCI insight
• 2017

Increased sugar consumption is a risk factor for the metabolic syndrome including obesity, hypertriglyceridemia, insulin resistance, diabetes, and nonalcoholic fatty liver disease (NAFLD).… (More)

Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice

• Nicholas Douris, Bhavna N. Desai, +9 authors Eleftheria Maratos-Flier
• Molecular metabolism
• 2017

OBJECTIVE We have previously shown that the consumption of a low-carbohydrate ketogenic diet (KD) by mice leads to a distinct physiologic state associated with weight loss, increased metabolic rate,… (More)

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