Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
ChREBP regulates fructose-induced glucose production independently of insulin signaling.
- Mi-sung Kim, Sarah A. Krawczyk, +10 authors M. Herman
- Medicine
- The Journal of clinical investigation
- 1 November 2016
Obese, insulin-resistant states are characterized by a paradoxical pathogenic condition in which the liver appears to be selectively insulin resistant. Specifically, insulin fails to suppress glucose… Expand
Intestinal, but not hepatic, ChREBP is required for fructose tolerance.
- Misung Kim, I. Astapova, +7 authors M. Herman
- Medicine
- JCI insight
- 21 December 2017
Increased sugar consumption is a risk factor for the metabolic syndrome including obesity, hypertriglyceridemia, insulin resistance, diabetes, and nonalcoholic fatty liver disease (NAFLD).… Expand
Activating Autophagy as a Therapeutic Strategy for Parkinson’s Disease
- Alan J. Fowler, C. Moussa
- Medicine
- CNS Drugs
- 28 February 2018
Parkinson’s disease is a progressive neurodegenerative disease characterized by Lewy body pathology of which the primary constituent is aggregated misfolded alpha-synuclein protein. Currently, there… Expand
Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice
- N. Douris, Bhavna N. Desai, +9 authors E. Maratos-Flier
- Biology, Medicine
- Molecular metabolism
- 6 June 2017
Objective We have previously shown that the consumption of a low-carbohydrate ketogenic diet (KD) by mice leads to a distinct physiologic state associated with weight loss, increased metabolic rate,… Expand
Pharmacokinetics and pharmacodynamics of a single dose Nilotinib in individuals with Parkinson's disease
- Fernando L. Pagan, M. Hebron, +14 authors C. Moussa
- Medicine
- Pharmacology research & perspectives
- 12 March 2019
Nilotinib is a broad‐based tyrosine kinase inhibitor with the highest affinity to inhibit Abelson (c‐Abl) and discoidin domain receptors (DDR1/2). Preclinical evidence indicates that Nilotinib… Expand
Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration
- Alan J. Fowler, M. Hebron, +5 authors C. Moussa
- Chemistry, Medicine
- Drugs in R&D
- 27 March 2019
Background and objectivesInhibition of Abelson (Abl) tyrosine kinase as a therapeutic target has been gaining attention in neurodegeneration. Post-mortem Alzheimer’s and Parkinson’s disease brains… Expand
Discoidin Domain Receptor 1 is a therapeutic target for neurodegenerative diseases.
- Alan J. Fowler, M. Hebron, +14 authors C. Moussa
- Biology, Medicine
- Human molecular genetics
- 8 August 2020
The role of Discoidin Domain Receptors (DDRs) is poorly understood in neurodegeneration. DDRs are upregulated in Alzheimer's and Parkinson's disease, and DDRs knockdown reduces neurotoxic protein… Expand
A NOVEL SMALL MOLECULE INHIBITOR OF THE DISCOIDIN DOMAIN RECEPTORS (DDR) REDUCES TAU AND AMYLOID-β AND IMPROVES COGNITION IN MODELS OF ALZHEIMER’S DISEASE
- Alan J. Fowler, M. Hebron, W. Shi, Alexander A. Missner, C. Moussa
- Psychology
- Alzheimer's & Dementia
- 1 July 2019
Author’s Reply to Segura-Aguilar: Autophagosome maturation not autophagy induction is impaired in neurodegeneration
- Alan J. Fowler, C. Moussa
- Medicine
- CNS Drugs
- 27 June 2018
The letter to the editor by Juan Segura-Aguilar [1] commenting on the manuscript by Fowler and Moussa titled ‘‘Activating autophagy as a therapeutic strategy for Parkinson’s disease’’ [2] is… Expand
4564 Nilotinib alters microRNAs that regulate specific autophagy and ubiquitination genes in the cerebrospinal fluid of Parkinson’s patients
- Alan J. Fowler, Yasar Torres-Yhagi, +8 authors C. Moussa
- Biology
- Journal of Clinical and Translational Science
- 1 June 2020
OBJECTIVES/GOALS: Our preclinical data demonstrate that the principal effects of nilotinib, a multi-tyrosine kinase inhibitor, in models of neurodegeneration is clearance of misfolded proteins via… Expand
...
1
2
...