Alan J.W. Woodward

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Large-scale patterns of land use and fragmentation have been associatedwith the decline of many imperiled wildlife populations. Lesserprairie-chickens(Tympanuchus pallidicinctus) are restricted to thesouthernGreat Plains of North America, and their population and range have declined by> 90% over the past 100 years. Our objective was to examine(More)
A sensitive high-performance liquid chromatographic (HPLC) assay for N-acetylcysteine in human plasma and urine has been developed. The method employs a prechromatographic stage to produce the dinitrophenyl derivative of N-acetylcysteine, which is chromatographed on a 5-microns C18 bonded reverse-phase column using an external standard method. The(More)
An accurate and sensitive method for the simultaneous determination of isosorbide dinitrate and its 2- and 5-mononitrates in human plasma has been developed. Following extraction of 3.0 ml of plasma with 12.0 ml of dichloromethane-ethyl acetate (1:1) the extract is subjected to high-performance liquid chromatography employing a Zorbax NH2 column. The eluent(More)
A highly selective and sensitive high-performance liquid chromatographic assay employing a thermal energy analyzer as the detector for nitroglycerin and its dinitrate metabolites in human plasma has been developed. Prior to chromatography the method employs a simple one-stage extraction step. Nitroglycerin and its dinitrate metabolites are then(More)
An improved method for the determination of N-acetylcysteine by paired-ion reversed-phase high-performance liquid chromatography has been developed. Following incubation with dithiothreitol to release bound N-acetylcysteine, free N-acetylcysteine and the internal standard N-acetylpenicillamine were derivatised with 2,4-dinitro-1-fluorobenzene. The samples(More)
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