Alan J. Kaplan

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BACKGROUND The standard management of early-stage invasive cervical cancer in early pregnancy is radical hysterectomy with the fetus in situ. We describe a case of early invasive cervical cancer in pregnancy that was treated with a conservative surgical approach. CASE A nulliparous pregnant women at 15 weeks of gestation was diagnosed with stage IA2(More)
UNLABELLED Study Type - Prognostic (cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Nomograms are based on large patient population. Their applicability should be externally validated. Among 747 brachytherapy patients we evaluated two Kattan nonograms and conclude that they have limited value to predict PSA-free(More)
A parallel strategy incorporating predictive modeling of both sodium site 2 blocking activity and cytochrome p450 CYP2D6 enzyme activity as well as experimental data from ADME profiling (eADME) has been applied to the design of new small molecule sodium channel blockers. New structural motifs were identified, which combined sodium channel activity with(More)
cont) results of simulation using real world demand data, which proved favorable to this approach. It discusses a modification to current approaches for determining cost of backorder. This report was motivated by concern with management of low failure items. For such items the discounted cash flow structure is most appropriate.
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