Alan Gratton

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The effects of the selective dopamine D1 and D2 receptor agonists, SKF 38393 and N-0437, respectively, on the firing rate of medial prefrontal cortex (PFC) neurons were studied in young (3-5 months old), and aged (18 and 26 months old) Fischer 344 rats. Multibarrel glass micropipettes, filled with 1 mM SKF 38393 and N-0437, were lowered into the(More)
  • A Gratton
  • Pharmacology, biochemistry, and behavior
  • 1982
The hypothesis of a serotonergic basis of reward rests partly on data showing that serotonin (5-HT) depletion by para-chlorophenylalanine (p-CPA) causes depression of self-stimulation (SS) rates. These data do not clearly demonstrate a time course relationship between 5-HT depletion and SS suppression. The present study shows that SS behavior has fully(More)
We used a delayed Cesarean birth model and the Golgi-Cox staining method to investigate the effects of perinatal anoxia on prefrontal cortex (PFC) and hippocampal (CA1) pyramidal neurons as well as nucleus accumbens (NAcc) medium spiny neurons. Dendritic morphology in these regions was studied on postnatal days (P) 2, 7, 14, 21, 35, and 70 in male(More)
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