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This paper presents a construction of a sequence of Kakutani-Rohlin Towers and a corresponding simple Bratteli Diagram, B, for a general minimal aperiodic Z d action on a Cantor Set, X, with d 2. This is applied to the description of the orbit structure and to the calculation of the ordered group of coinvariants. For each minimal continuous Z d action on X(More)
In the plant genus Silene, separate sexes and sex chromosomes are believed to have evolved twice. Silene species that are wholly or largely hermaphroditic are assumed to represent the ancestral state from which dioecy evolved. This assumption is important for choice of outgroup species for inferring the genetic and chromosomal changes involved in the(More)
To characterize temporal exposure and elimination of 5 gold/dendrimer composite nanodevices (CNDs) (5 nm positive, negative, and neutral, 11 nm negative, 22 nm positive) in mice using a physiologically based mathematical model. 400 ug of CNDs is injected intravenously to mice bearing melanoma cell lines. Gold content is determined from plasma and tissue(More)
Numerous factors have been theorized to affect the development of antimicrobial resistance, including those specific to the host, the organism, the environment, the drug, and the drug prescriber. One variable under the control of the prescriber is the drug dosing regimen. Dosing regimens can vary in dose level, dosing interval, and treatment duration. The(More)
PURPOSE To evaluate a semi-parametric, model-based approach for obtaining transcription rates from mRNA and protein expression. METHODS The transcription profile input was modeled using an exponential function of a cubic spline and the dynamics of translation; mRNA and protein degradation were modeled using the Hargrove-Schmidt model. The transcription(More)
We present a systematic treatment of the commutative and non-commutative topol-ogy of quasicrystal point patterns and tilings produced in nite dimensional Euclidean space by the projection or strip method. With no conditions on the projection plane and with a general acceptance domain only weakly constrained, we examine two sets of points constructed by the(More)
Polymyxins are often last-line therapeutic agents used to treat infections caused by multidrug-resistant A. baumannii. Recent reports of polymyxin-resistant A. baumannii highlight the urgent need for research into mechanisms of polymyxin resistance. This study employed genomic and transcriptomic analyses to investigate the mechanisms of polymyxin resistance(More)
Multidrug-resistant Acinetobacter baumannii presents a global medical crisis and polymyxins are used as the last-line therapy. This study aimed to identify metabolic differences between polymyxin-susceptible and polymyxin-resistant A. baumannii using untargeted metabolomics. The metabolome of each A. baumannii strain was measured using liquid(More)