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  • Hiroyuki Sato, Antonio Macchiarulo, +7 authors Johan Auwerx
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 1 March 2008
  • TGR5, a metabotropic receptor that is G-protein-coupled to the induction of adenylate cyclase, has been recognized as the molecular link connecting bile acids to the control of energy and glucoseContinue Reading
  • Kazuya Maeda, Miyuki Kambara, Ying Tian, Alan F. Hofmann, Yuichi Sugiyama
  • Chemistry, Medicine
  • Molecular pharmaceutics
  • 1 February 2006
  • Ursodeoxycholate (UDCA) is widely used for the treatment of cholestatic liver disease. After oral administration, UDCA is absorbed, taken up efficiently by hepatocytes, and conjugated mainly withContinue Reading
  • Takashi Iida, Shoujiro Ogawa, +6 authors Alan F. Hofmann
  • Chemistry, Medicine
  • The Journal of organic chemistry
  • 1 February 2007
  • tert-Butyl hydroperoxide catalyzed by (5,10,15,20-tetramesitylporphyrinate) osmium(II) carbonyl [Os(TMP)CO] complex was found to be a highly efficient versatile oxidant for C-H carbons in steroidContinue Reading