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ATOM (Analysis Tools with OM) is a single framework for building a wide range of customized program analysis tools. It provides the common infrastructure present in all code-instrumenting tools; this is the difficult and time-consuming part. The user simply defines the tool-specific details in instrumentation and analysis routines. Building a basic block(More)
The Western Research Laboratory (WRL) is a computer systems research group that was founded by Digital Equipment Corporation in 1982. Our focus is computer science research relevant to the design and application of high performance scientific computers. We test our ideas by designing, building, and using real systems. The systems we build are research(More)
Identifying variables as invariant or constant at compile-time allows the compiler to perform optimizations including constant folding, code specialization, and partial evaluation. Some variables, which cannot be labeled as constants, may exhibit semi-invariant behavior. A "semi-invariant" variable is one that cannot be identified as a constant at(More)
Variables and instructions that have invariant or predictable values at run-time, but cannot be identified as such using compiler analysis, can benefit from value-based compiler optimizations. Value-based optimizations include all optimizations based on a predictable value or range of values for a variable or instruction at run-time. These include constant(More)
BACKGROUND As degradation of formalin-fixed paraffin-embedded (FFPE) samples limits the ability to profile mRNA expression, we explored factors predicting the success of mRNA expression profiling of FFPE material and investigated an approach to overcome the limitation. METHODS Bladder (n=140, stored 3-8 years) and cervix (n=160, stored 8-23 years)(More)
This paper proposes a novel solution to querying hyperlinked multimedia cultural heritage datasets based on the user's context. Context in this sense is defined as the user's location in virtual space and the particular mobile device b eing modelled together with user preferences or profile. The purpose is to automatically push relevant data from the(More)
Variables and instructions that have invariant or predictable values at run-time, but cannot be identiied as such using compiler analysis, can beneet from value-based compiler optimizations. Value-based optimizations include all optimizations based on a predictable value or range of values for a variable or instruction at run-time. These include constant(More)
BACKGROUND The addition of carbogen and nicotinamide (CON) to radiotherapy (RT) improves overall survival in invasive bladder cancer. We explored whether expression of the hypoxia marker hypoxia-inducible factor-1α (HIF-1α) alone or in combination with other markers predicted benefit from CON. METHODS A retrospective study was carried out using material(More)
BACKGROUND The addition of hypoxia modifiers carbogen and nicotinamide (CON) to radiotherapy (RT) improved overall survival (OS) in bladder cancer patients in the BCON phase III clinical trial. We investigate whether expression of hsa-miR-210 in BCON patient samples reflects hypoxia and predicts benefit from hypoxia modification. METHODS In all, 183(More)