Alan E. McKinnon

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We have previously described a model for corticotroph plasma membrane electrophysiology [LeBeau et al. (1997). Biophysical Journal 73, 1263-1275]. The model is a Hodgkin-Huxley-like formalism consisting of six coupled ordinary differential equations. Analysis of this model showed that Ca2+ action potentials could be induced by an increase in the L-type(More)
Corticotropin-releasing hormone (CRH) is an important regulator of adrenocorticotropin (ACTH) secretion from pituitary corticotroph cells. The intracellular signaling system that underlies this process involves modulation of voltage-sensitive Ca2+ channel activity, which leads to the generation of Ca2+ action potentials and influx of Ca2+. However, the(More)
Pituitary corticotroph cells generate repetitive action potentials and associated Ca2+ transients in response to the agonist corticotropin releasing hormone (CRH). There is indirect evidence suggesting that the agonist, by way of complex intracellular mechanisms, modulates the voltage sensitivity of the L-type Ca2+ channels embedded in the plasma membrane.(More)
—This paper presents a technique to identify and measure the prominent sources of sensor noise in commercially available charge-coupled device (CCD) video cameras by analysis of the output images. Noise fundamentally limits the distin-guishable content in an image and can significantly reduce the robustness of an image processing application. Although(More)
A desktop Virtual Reality (VR) application of a skim milk powder process has been developed. The goal was to use this application as a learning resource to expose students to processing plant environments, which are becoming increasingly difficult to visit due to availability and safety reasons. The VR application comprises 360° panorama images of the(More)
Noise affects all captured images, regardless of the quality of the image sensor. One of the major contributors to image noise is heat within the sensor, where variations in thermally generated currents results in a fluctuation of measured pixel values. These fluctuations can severely impact on the robustness of applications that process the resultant(More)
In this project a 3-dimensional virtual world is consructed with the use of a LEGO camera and a set of LEGO blocks. The goal is to design a construction method that is simple enough for middle school-aged children to use and at the same time is able to produce quality models for higher end users. The method was developed using RoboLab and involves a(More)
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