Alan E. McKinnon

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We have previously described a model for corticotroph plasma membrane electrophysiology [LeBeau et al. (1997). Biophysical Journal 73, 1263-1275]. The model is a Hodgkin-Huxley-like formalism consisting of six coupled ordinary differential equations. Analysis of this model showed that Ca2+ action potentials could be induced by an increase in the L-type(More)
Corticotropin-releasing hormone (CRH) is an important regulator of adrenocorticotropin (ACTH) secretion from pituitary corticotroph cells. The intracellular signaling system that underlies this process involves modulation of voltage-sensitive Ca2+ channel activity, which leads to the generation of Ca2+ action potentials and influx of Ca2+. However, the(More)
Pituitary corticotroph cells generate repetitive action potentials and associated Ca2+ transients in response to the agonist corticotropin releasing hormone (CRH). There is indirect evidence suggesting that the agonist, by way of complex intracellular mechanisms, modulates the voltage sensitivity of the L-type Ca2+ channels embedded in the plasma membrane.(More)
—This paper presents a technique to identify and measure the prominent sources of sensor noise in commercially available charge-coupled device (CCD) video cameras by analysis of the output images. Noise fundamentally limits the distin-guishable content in an image and can significantly reduce the robustness of an image processing application. Although(More)
An extension of the previously proposed model of Mg metabolism (Robson et al. 1997) has been developed to consider the transactions of Mg that are associated with cerebrospinal fluid (CSF) and bone. The representation of the CSF as a single MG compartment with uptake from the plasma described by Michaelis-Menten kinetics gives very good agreement with(More)
A desktop Virtual Reality (VR) application of a skim milk powder process has been developed. The goal was to use this application as a learning resource to expose students to processing plant environments, which are becoming increasingly difficult to visit due to availability and safety reasons. The VR application comprises 360° panorama images of the(More)
Noise affects all captured images, regardless of the quality of the image sensor. One of the major contributors to image noise is heat within the sensor, where variations in thermally generated currents results in a fluctuation of measured pixel values. These fluctuations can severely impact on the robustness of applications that process the resultant(More)
EXTENDED ABSTRACT The onset of tetany, when dairy cattle have insufficient magnesium, has a huge impact both economically and on animal welfare. We have previously adapted a model of magnesium dynamics in sheep (Robson et al. 1997) for use with dairy cattle as an aid to understanding aspects of magnesium metabolism which influence the risk of animals(More)
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