Alan E. McKinnon

Learn More
Corticotropin-releasing hormone (CRH) is an important regulator of adrenocorticotropin (ACTH) secretion from pituitary corticotroph cells. The intracellular signaling system that underlies this process involves modulation of voltage-sensitive Ca2+ channel activity, which leads to the generation of Ca2+ action potentials and influx of Ca2+. However, the(More)
Mass spectrometers produce distorted measurements of gas concentrations because of the time delays and rise times inherent in their responses. Three techniques for numerically correcting such distortion were applied to the acetylene step responses of a Perkin-Elmer MGA1100 mass spectrometer and to simulated data. The techniques investigated were 1) a simple(More)
We have previously described a model for corticotroph plasma membrane electrophysiology [LeBeau et al. (1997). Biophysical Journal 73, 1263-1275]. The model is a Hodgkin-Huxley-like formalism consisting of six coupled ordinary differential equations. Analysis of this model showed that Ca2+ action potentials could be induced by an increase in the L-type(More)
Pituitary corticotroph cells generate repetitive action potentials and associated Ca2+ transients in response to the agonist corticotropin releasing hormone (CRH). There is indirect evidence suggesting that the agonist, by way of complex intracellular mechanisms, modulates the voltage sensitivity of the L-type Ca2+ channels embedded in the plasma membrane.(More)
A pilot evaluation of a simulation program used during a tutorial for the teaching of uptake and distribution of the inhalational anaesthetic halothane shows a highly significant improvement in the students' answers after the tutorial using a 'before and after' questionnaire. The students showed an understanding of the program's display and model(More)
This paper presents a technique to identify and measure the prominent sources of sensor noise in commercially available charge-coupled device (CCD) video cameras by analysis of the output images. Noise fundamentally limits the distinguishable content in an image and can significantly reduce the robustness of an image processing application. Although sources(More)
Standard methods of measuring the diffusing capacity of the lung for CO are susceptible to inhomogeneity and to errors in the performance of a breathing maneuver by the subject. A mathematical model of CO uptake from a single alveolar lung is developed and used as the basis for an estimation procedure to measure both lung volume and diffusing capacity(More)
A computer aided learning program for teaching the kinetics of uptake and distribution of the inhalational anaesthetic halothane is described. The program is based on a seven-compartment model which simulates the action of halothane on ventilation and on the cardiovascular system. The program is available to the student in four forms: one with no changes in(More)
A bag-in-box system (BBS) whose volume is monitored by a mechanical spirometer tends to have a slow response if the volume of the box is large, and this may significantly affect its measurement of gas flow. We describe a device for creating reproducible gas flows with which the impulse response of a BBS may be conveniently determined. Two computational(More)
A desktop Virtual Reality (VR) application of a skim milk powder process has been developed. The goal was to use this application as a learning resource to expose students to processing plant environments, which are becoming increasingly difficult to visit due to availability and safety reasons. The VR application comprises 360° panorama images of the(More)