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We illustrate data analytic concerns that arise in the context of relating genotype, as represented by amino acid sequence, to phenotypes (outcomes). The present application examines whether peptides that bind to a particular major histocompatibility complex (MHC) class I molecule have characteristic amino acid sequences. However, the concerns identified(More)
SUMMARY For many sources of survival data, there is a delay between the recording of vital status and its availability to the analyst, and the Kaplan-Meier estimator is typically inconsistent in these situations. In this paper we identify the optimal estimation problem. As a result of the curse of dimensionality, no globally efficient nonparametric(More)
"Dehalococcoides" bacteria can reductively dehalogenate a wide range of halogenated organic pollutants. In this study, DNA microarrays were used to monitor dynamic changes in the transcriptome as "Dehalococcoides ethenogenes" strain 195 transitioned from exponential growth into stationary phase. In total, 415 nonredundant genes were identified as(More)
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. The goal of the Lower Hybrid Current Drive ͑LHCD͒ system on the Alcator C-Mod(More)
  • ALCATOR C-MOD, N. P. BASSE, +20 authors K. ZHUROVICH
  • 2006
An overview of the diagnostics installed on the Alcator C-Mod tokamak [I.] is presented. Approximately twenty-five diagnostic systems are being operated on C-Mod. The compact design of the machine and the cryostat enclosing the vacuum vessel and magnetic field coils make access challenging. Diagnostics are used to study four focus areas: Transport, plasma(More)
The Thomson scattering (TS) diagnostics set [Rev.] has been upgraded to deliver measurements of electron temperature (T e) and density (n e) with improved temporal and spatial resolution. Two 30 Hz, 1.3 J Nd-doped yttrium aluminum garnet (Nd:YAG) lasers share a vertical beam path through the tokamak plasma and are fired in alternating fashion, allowing(More)
An improved energy confinement regime, I-mode is studied in Alcator C-Mod, a compact high-field divertor tokamak using Ion Cyclotron Range of Frequencies (ICRF) auxiliary heating. I-mode features an edge energy transport barrier without an accompanying particle barrier, leading to several performance benefits. H-mode energy confinement is obtained without(More)
In Alcator C-Mod discharges lower hybrid waves have been shown to induce a countercurrent change in toroidal rotation of up to 60 km/s in the central region of the plasma (r/a approximately <0.4). This modification of the toroidal rotation profile develops on a time scale comparable to the current redistribution time (approximately 100 ms) but longer than(More)
Citation McDermott, R. M. et al. " Edge radial electric field structure and its connections to H-mode confinement in Alcator C-Mod plasmas. Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available.(More)
We consider the problem of constructing confidence intervals for the mean of a Negative Binomial random variable based upon sampled data. When the sample size is large, it is a common practice to rely upon a Normal distribution approximation to construct these intervals. However, we demonstrate that the sample mean of highly dispersed Negative Binomials(More)