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Therapeutic drug monitoring (TDM) is the measurement of serum or plasma drug concentration to allow the individualization of dosing. We describe the case of a patient who was prescribed inappropriately large doses of vancomycin due to inaccurate TDM. Specifically, our laboratory reported progressively lower vancomycin concentrations despite dose increases.(More)
BACKGROUND Paediatric reference intervals are less well characterized than in adults. An initiative for harmonization of pathology across the United Kingdom has recommended an interval for sodium of 133-146 mmol/L at all ages. METHODS To assess the validity of this, the laboratory database was interrogated for all renal profiles (sodium, potassium, urea(More)
Background Tandem mass spectrometry (MS/MS) has recently become an alternative method for the newborn screening of sickle cell disorders (SCD), as it is able to detect haemoglobin (Hb) peptides following digestion of bloodspots with trypsin. Using the SpOtOn Diagnostics Reagent Kit, we previously developed a screening protocol to detect only the disease(More)
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