Alan Dal Pra

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In a recent Oncogene review, Yen et al. summarized the important role of somatic mutations in the cytoplasmic and mitochondrial forms of isocitrate dehydrogenase (IDH1 and IDH2, respectively) in cancer. These gliomaand acute myeloid leukemia-associated mutations occur at IDH1 codon 132 (that is, R132) or in IDH2, at codon 172 or 140 (that is, R172, R140).(More)
BACKGROUND Consensus-based approaches provide an alternative to evidence-based decision making, especially in situations where high-level evidence is limited. Our aim was to demonstrate a novel source of information, objective consensus based on recommendations in decision tree format from multiple sources. METHODS Based on nine sample recommendations in(More)
External beam radiotherapy (EBRT), with or without androgen deprivation therapy (ADT), is an established treatment option for nonmetastatic prostate cancer. Despite high-level evidence from several randomized trials, risk group stratification and treatment recommendations vary due to contradictory or inconclusive data, particularly with regard to EBRT dose(More)
The combined use of androgen deprivation therapy (ADT) and image-guided radiotherapy (IGRT) can improve overall survival in aggressive, localized prostate cancer. However, owing to the adverse effects of prolonged ADT, it is imperative to identify the patients who would benefit from this combined-modality therapy relative to the use of IGRT alone.(More)
Radiation therapy (RT) is one of the mainstay treatments for prostate cancer (PCa). The potentially curative approaches can provide satisfactory results for many patients with non-metastatic PCa; however, a considerable number of individuals may present disease recurrence and die from the disease. Exploiting the rich molecular biology of PCa will provide(More)
Background: Preclinical data suggest that TMPRSS2-ERG gene fusions, present in about 50% of prostate cancers, may be a surrogate for DNA repair status and therefore a biomarker for DNA-damaging agents. To test this hypothesis, we examined whether TMPRSS2-ERG status was associated with biochemical failure after clinical induction of DNA damage following(More)
Nutrition is a crucial topic in oncology, a worsening in nutritional status being able to influence both the course of the disease and its outcome. Malnutrition is a pathological state characterized by an inadequate intake of energy and/or nutrients to meet the biological needs of the body, leading to a systemic catabolic state with potentially reversible(More)
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