• Publications
  • Influence
A unified statistical approach for determining significant signals in images of cerebral activation
TLDR
A unified statistical theory for assessing the significance of apparent signal observed in noisy difference images is presented and an estimate of the P‐value for local maxima of Gaussian, t, χ2 and F fields over search regions of any shape or size in any number of dimensions is estimated. Expand
A Three-Dimensional Statistical Analysis for CBF Activation Studies in Human Brain
TLDR
A simple method for determining an approximate p value for the global maximum based on the theory of Gaussian random fields is described, which focuses on the Euler characteristic of the set of voxels with a value larger than a given threshold. Expand
Assessing the significance of focal activations using their spatial extent
TLDR
The results mean that detecting significant activations no longer depends on a fixed threshold, but can be effected at any (lower) threshold, in terms of the spatial extent of the activated region. Expand
Brain development during childhood and adolescence: a longitudinal MRI study
TLDR
This large-scale longitudinal pediatric neuroimaging study confirmed linear increases in white matter, but demonstrated nonlinear changes in cortical gray matter, with a preadolescent increase followed by a postadolescent decrease. Expand
A nonparametric method for automatic correction of intensity nonuniformity in MRI data
TLDR
A novel approach to correcting for intensity nonuniformity in magnetic resonance (MR) data is described that achieves high performance without requiring a model of the tissue classes present, and is applied at an early stage in an automated data analysis, before a tissue model is available. Expand
Combining Spatial Extent and Peak Intensity to Test for Activations in Functional Imaging
TLDR
This paper combines two tests used to assess the regional significance in functional images into a single test that is more sensitive to a wider range of signals, based on an analytical approximation of the distribution of these two parameters (size and height). Expand
Neurodevelopmental Trajectories of the Human Cerebral Cortex
TLDR
By mapping a key characteristic of these development trajectories (the age of attaining peak cortical thickness), this work documents the dynamic, heterochronous maturation of the cerebral cortex through time lapse sequences (“movies”). Expand
BrainWeb: Online Interface to a 3D MRI Simulated Brain Database
TLDR
BrainWeb makes available to the neuroimaging community, online on WWW, a set of realistic simulated brain MR image volumes (Simulated Brain Database, SBD) that allows the above issues to be examined in a controlled, systematic way. Expand
Small-world anatomical networks in the human brain revealed by cortical thickness from MRI.
TLDR
This study investigated large-scale anatomical connection patterns of the human cerebral cortex using cortical thickness measurements from magnetic resonance images and showed that the human brain anatomical network had robust small-world properties with cohesive neighborhoods and short mean distances between regions that were insensitive to the selection of correlation thresholds. Expand
Unbiased average age-appropriate atlases for pediatric studies
TLDR
The methods used to create unbiased, age-appropriate MRI atlas templates for pediatric studies that represent the average anatomy for the age range of 4.5-18.5 years are presented, while maintaining a high level of anatomical detail and contrast. Expand
...
1
2
3
4
5
...