Alain Tremblay

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This paper presents the results of the implementation of a genetic algorithm for the geometrical synthesis of parallel manipulators of the Star-like topology. The algorithm allows one to use several design criteria while considering a population of potential designs. The algorithm has proven to be simple and eeective. Although the Y Star parallel(More)
The mechanisms by which Regulatory T cells suppress IL-2 production of effector CD4+ T cells in pathological conditions are unclear. A subpopulation of human Treg expresses the ectoenzyme CD39, which in association with CD73 converts ATP/ADP/AMP to adenosine. We show here that Treg/CD39+ suppress IL-2 expression of activated CD4+ T-cells more efficiently(More)
BACKGROUND It is estimated that millions of North Americans would qualify for lung cancer screening and that billions of dollars of national health expenditures would be required to support population-based computed tomography lung cancer screening programs. The decision to implement such programs should be informed by data on resource utilization and(More)
Interleukin-8 (IL-8) plays key roles in both chronic inflammatory diseases and tumor modulation. We previously observed that IL-8 secretion and function can be modulated by nucleotide (P2) receptors. Here we investigated whether IL-8 release by intestinal epithelial HT-29 cells, a cancer cell line, is modulated by extracellular nucleotide metabolism. We(More)
Increasing rates of opioid abuse, particularly fentanyl, may lead to more presentations of unusual effects of opioid toxicity. Diffuse alveolar hemorrhage is a rare complication of fentanyl overdose. A 45-year-old male presented in hypoxic respiratory failure secondary to diffuse alveolar hemorrhage requiring intubation. Comprehensive drug screening(More)
The role of greenhouse gas emissions (GHG) from freshwater reservoirs and their contribution in increasing atmospheric GHG concentrations is actually well discussed worldwide. The amount of GHGs emitted at the air-water interface of reservoirs varies over time. The maximum is attained within 3 to 5 years after impoundment. In reservoirs older >10 years in(More)
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