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Flavusides A and B, antibacterial cerebrosides from the marine-derived fungus Aspergillus flavus.
Flavusides A and B and two new antibacterial cerebroside derivatives have been isolated from the extract of a marine isolate of the fungus Aspergillus flavus and the structure and absolute stereochemistry of two cerebrosides were assigned on the basis of NMR and Tandem FAB-MS/MS experiments. Expand
Extreme effects of Seabuckthorn extracts on influenza viruses and human cancer cells and correlation between flavonol glycosides and biological activities of extracts
Correlation study reveals that aglycones and flavonol mono-glycosides highly correlated with anti-influenza activities but not correlated with anticancer activities, and di- glycosides and tri-glyCosides have a high correlation with cytotoxic effect with both normal and cancer cells. Expand
Diacetoxyscirpenol as a new anticancer agent to target hypoxia-inducible factor 1
Dacetoxyscirpenol is considered a potential drug deregulating the HIF-1 signaling pathway, and it could be beneficially employed for treating malignant tumors with hypoxic microenvironment. Expand
Anti-Pigmentary Effect of (-)-4-Hydroxysattabacin from the Marine-Derived Bacterium Bacillus sp.
The anti-melanogenic effects of (-)-4-hydroxysattabacin were further demonstrated in a pigmented 3D human epidermal skin model, MelanodermTM, and manifested as whitening and regression of melanocyte activation in the tissue. Expand
Cristazine, a New Cytotoxic Dioxopiperazine Alkaloid from the Mudflat-Sediment-Derived Fungus Chaetomium cristatum.
A new class of dioxopiperazine alkaloid was isolated from the mudflat-sediment-derived fungus Chaetomium cristatum and displayed potent radical-scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and cytotoxic activity against human cervical carcinoma cells. Expand
New production of 5-bromotoluhydroquinone and 4-O-methyltoluhydroquinone from the marine-derived fungus Dothideomycete sp.
The addition of NaBr to the fermentation medium of a marine isolate of the fungus Dothideomycete sp. resulted in induced production of two toluhydroquinone derivatives, 5- bromotoluhydroquinone (1)Expand
An Acetophenone Derivative, Clavatol, and a Benzodiazepine Alkaloid, Circumdatin A, from the Marine-Derived Fungus Cladosporium
The crude extract of the mycelium of Cladosporium was found to exhibit antimicrobial activity against the Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus.Expand
Induced production of 6,9-dibromoflavasperone, a new radical scavenging naphthopyranone in the marine-mudflat-derived fungus Aspergillus niger
The addition of metal bromides during fermentation of the marine-mudflat-derived fungus Aspergillus niger induced production of a new radical scavenging brominated naphthopyranone, 6,9-dibromoflavasperone, which displayed potent radical scavenge activity against 2,2-diphenyl-1-picrylhydrazyl. Expand
Nocarimidazoles A and B from a Marine-Derived Actinomycete of the Genus Nocardiopsis.
The chemical structures of nocarimidazoles A and B were assigned by interpretation of NMR spectroscopic data and through methylation to yield monomethyl and dimethyl derivatives. Expand
Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis
A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1Expand