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Fluorescence in situ hybridization signals on human metaphase chromosomes are detected by a near-field scanning optical microscope. This makes it possible to localize and identify several fluorescently labeled genomic DNA fragments on a single chromosome with a resolution superior to traditional fluorescence microscopy. Several nucleic acid probes have been(More)
The inverse problem of estimating the Particle Size Distribution (PSD) from Multiangle Dynamic Light Scattering measurements (MDLS) is considered using a Bayesian inference approach. We propose to model the multimodal PSD as a normal mixture with an unknown number of components (modes or peaks). In order to achieve the estimation of these variable dimension(More)
We present a novel Q-switched laser source using a micro-optical-electromechanical mirror (MOEM) designed for short pulse emission. It is based on a hybrid configuration including a passively Q-switched microchip laser coupled to a fiber cavity closed by a cantilever type MOEM acting as an active modulator. This specially designed mirror with a single(More)
Taking advantage of the combination of stimulated Raman scattering and nonlinear polarization rotation in a single-mode optical fiber, a temporal reshaping of subnanosecond pulses is achieved by means of both spectral and polarization filtering. Shortening of 650 ps down to 43 ps temporally and spectrally stable pulses is experimentally obtained. Numerical(More)
Recovering the particle size distribution (PSD) from dynamic light scattering (DLS) measurements is known to be a highly ill-posed inverse problem. In a former study, we proposed a new Bayesian inference method applied directly to the multiangle DLS measurements to improve the estimation of multimodal PSDs. The posterior probability density of interest is(More)
We present a scanning near-field optical microscope operating in reflection suitable for simultaneous bright field and fluorescence imaging. A non-coated pulled optical fibre is used in true reflection mode, i.e. both as emitter and collector. Beam splitters, dichroic mirrors and polarisers are combined to discriminate the different wavelength and(More)
We derive the Cramér-Rao lower bounds (CRB) for parametric estimation of the number-weighted particle size distribution (PSD) from multiangle Dynamic Light Scattering (DLS) measurements. The CRB is a useful statistical tool to investigate the optimality of the PSD estimators. In the present paper, a Gaussian mixture (GM) model of the multimodal PSD(More)
Dynamic Light Scattering (DLS) is a widely used technique for measuring the size distributions of nano- and micro-particles dispersed in a liquid. The principle is based on the analysis of the temporal fluctuations of light scattered by the particles at a given scattering angle. However, single-angle DLS measurements may lack resolution and robustness,(More)
A temporal shortening by a factor higher than 10 of subnanosecond pulses launched into a low-birefringence optical fiber is achieved by polarization filtering at the output. By means of the theoretical approach, in good agreement with experimental measurements, the impact of the nonlinear polarization rotation and of the coherent coupling phenomena is(More)