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Fluorescence in situ hybridization signals on human metaphase chromosomes are detected by a near-field scanning optical microscope. This makes it possible to localize and identify several fluorescently labeled genomic DNA fragments on a single chromosome with a resolution superior to traditional fluorescence microscopy. Several nucleic acid probes have been(More)
The inverse problem of estimating the Particle Size Distribution (PSD) from Multiangle Dynamic Light Scattering measurements (MDLS) is considered using a Bayesian inference approach. We propose to model the multimodal PSD as a normal mixture with an unknown number of components (modes or peaks). In order to achieve the estimation of these variable dimension(More)
Recovering the particle size distribution (PSD) from dynamic light scattering (DLS) measurements is known to be a highly ill-posed inverse problem. In a former study, we proposed a new Bayesian inference method applied directly to the multiangle DLS measurements to improve the estimation of multimodal PSDs. The posterior probability density of interest is(More)
We derive the Cramér-Rao lower bounds (CRB) for parametric estimation of the number-weighted particle size distribution (PSD) from multiangle Dynamic Light Scattering (DLS) measurements. The CRB is a useful statistical tool to investigate the optimality of the PSD estimators. In the present paper, a Gaussian mixture (GM) model of the multimodal PSD(More)
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