Alain Hassoun

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Tacrolimus is extensively metabolized by the cytochrome P-450 system. Hepatic metabolic phase I reactions of tacrolimus include mainly demethylation and/or hydroxylation. No valid data have been published on phase II pathways (glucuronide- or sulfo-conjugation). In order to investigate these pathways, different β-glucuronidase/sulfatase enzyme preparations(More)
SPECT∗ image based diagnosis generally consists in comparing the reconstructed activities within two regions of interest. Due to noise in the measured activities, this comparison is subject to instability, mainly because both statistical nature and level of the noise in the reconstructed activities is unknown. In this paper, we experimentally show that an(More)
The method is based mainly on the extraction of the substance by a small volume of organic solvent from an alkaline medium containing a fairly important amount of inorganic salt. The extract is then subjected to thin layer and/or gas chromatography. The authors present also the relative frequency that they met on hexapropymate intoxications together with(More)
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