Alain Beck

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Strategies and challenges for the next generation of antibody–drug conjugates

Alain Beck, Liliane Goetsch, Charles Dumontet, Nathalie Corvaïa
Nature Reviews Drug Discovery
2017

Antibody–drug conjugates (ADCs) are one of the fastest growing classes of oncology therapeutics. After half a century of research, the approvals of brentuximab vedotin (in 2011) and trastuzumab… (More)

Characterization of therapeutic antibodies and related products.

Alain Beck, Elsa Wagner-Rousset, Daniel Ayoub, Alain van Dorsselaer, Sarah Sanglier-Cianférani
Analytical chemistry
2013

Correct primary structure assessment and extensive glyco-profiling of cetuximab by a combination of intact, middle-up, middle-down and bottom-up ESI and MALDI mass spectrometry techniques

Daniel B. Ayoub, Wolfgang Jabs, +7 authors Alain Beck
mAbs
2013

The European Medicines Agency received recently the first marketing authorization application for a biosimilar monoclonal antibody (mAb) and adopted the final guidelines on biosimilar mAbs and… (More)

Strategies and challenges for the next generation of therapeutic antibodies

Alain Beck, Thierry Wurch, Christian Bailly, Nathalie Corvaia
Nature Reviews Immunology
2010

Antibodies and related products are the fastest growing class of therapeutic agents. By analysing the regulatory approvals of IgG-based biotherapeutic agents in the past 10 years, we can gain… (More)

Trends in glycosylation, glycoanalysis and glycoengineering of therapeutic antibodies and Fc-fusion proteins.

Alain Beck, Elsa Wagner-Rousset, +7 authors Nathalie Corvaïa
Current pharmaceutical biotechnology
2008

Monoclonal antibodies (MAbs) are the fastest growing class of human pharmaceuticals. More than 20 MAbs have been approved and several hundreds are in clinical trials in various therapeutic… (More)

A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human…

Liliane Goetsch, Alexandra González, +4 authors Nathalie Corvaia
International journal of cancer
2005

Interaction of insulin-like growth factor receptor I (IGF-IR) with its ligands has been reported to induce cell proliferation, transformation and blockade of cell apoptotic functions. IGF-IR is… (More)

Middle-down analysis of monoclonal antibodies with electron transfer dissociation orbitrap fourier transform mass spectrometry.

Luca Fornelli, Daniel Ayoub, Konstantin Aizikov, Alain Beck, Yury O Tsybin
Analytical chemistry
2014

The rapid growth of approved biotherapeutics, e.g., monoclonal antibodies or immunoglobulins G (IgGs), demands improved techniques for their quality control. Traditionally, proteolysis-based… (More)

Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion

Elsa Wagner-Rousset, Marie-Claire Janin-Bussat, +7 authors Alain Beck
mAbs
2014

Here we report the design and production of an antibody-fluorophore conjugate (AFC) as a non-toxic model of an antibody-drug conjugate (ADC). This AFC is based on the conjugation of dansyl… (More)

Marketing approval of mogamulizumab

Therapeutic properties of antibodies strongly depend on the composition of their glycans. Most of the currently approved antibodies are produced in mammalian cell lines, which yield mixtures of… (More)

Alain Beck, Sarah Sanglier-Cianférani, Alain van Dorsselaer
Analytical chemistry
2012

This Feature will introduce the strategies of therapeutic antibodies (mAbs) in-depth characterization by mass spectrometry (MS) and discuss analytical comparison of biosimilar to originator mAbs,… (More)

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