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This paper outlines the research methodology, conceptual framework, and some preliminary research results for a longitudinal and holistic study of the impact and management of information technology in two governments considered by knowledgeable observers to be in the forefront, the federal Government of Canada and the Province of Ontario. The methodology(More)
Anti-AChR is heterogeneous within individuals and between individuals. Anti-AChR idiotypes are not shared to any large extent. Ten monoclonal antibodies raised against human AChR: (a) bind to five partially overlapping regions; (b) are not idiotypically identical even within a region; (c) do not all bind to the main immunogenic region; (d) four distinguish(More)
Certain cancers exert unexplained remote effects on the nervous system. Small cell carcinoma (SCC) of the lung, a tumour capable of spike electrogenesis and which is of possible neural crest origin, is present in approximately 70% of patients with the Lambert-Eaton myasthenic syndrome (LEMS), a disorder characterized by fatigable muscle weakness. Patients(More)
Monoclonal antibodies have been shown to bind to five regions on human acetylcholine receptor, each probably consisting of a discrete epitope on the extracellular surface. Two of these regions are equivalent to the 'main immunogenic region', and the other three appear to be close to the a-Bungarotoxin binding sites. These antibodies have been used to probe(More)
Myasthenia gravis patients have serum anti-acetylcholine receptor antibodies that compete with monoclonal antibodies for binding to epitopes on the human acetylcholine receptor. To investigate the presence of shared idiotypes we immunised syngeneic mice with each of ten well-characterised monoclonal antibodies, previously raised against purified human(More)
Anti-idiotype sera, raised in rabbits against anti-acetylcholine receptor (AChR) (idiotype) purified from the serum of three myasthenia gravis patients, inhibited binding of homologous idiotype to the AChR by up to 80%. The expression of idiotype in the three individuals changed very little over a period of several years, during which they showed a(More)
In the middle to late 1960's Murray Turoff and his colleagues in the Office of Emergency Preparedness, Executive Office of the Presi dent, were "bootlegging" (that is, without formal approval) the development of computerized conferencing and terminals to transmit , store and forward messages among geographically dispersed participants. Of course, the(More)
The Kershaw Award is made every two years to a scholar under the age of 40 who has made a significant contribution to policy and management. The award honors David Kershaw, the first President of Mathematica, who died of cancer at the age of 37. 2 Thanks and Acknowledgments It is a great honor to receive this award. I have a lot of thanks to give, but will(More)
SIGSOC Bulletin examples are presented which further exemplify the principle and its application. Specific references are provided for all principles except those few which are the authors' inferences based on research literature. The book is well organized around the defined principles and provides the reader with a general understanding of the currently(More)
The mouse monoclonal antibody (m.ab) binding sites on human acetylcholine receptor have been mapped by inhibition by F(ab')2 m.ab fragments, by competition with a rat m.ab against the main immunogenic region (anti-m.i.r), and by their ability to protect the a-Bungarotoxin (a-BuTx) binding sites from inhibition by a myasthenia gravis (MG) plasma. Two m.abs(More)