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OBJECTIVE To evaluate the impact of state supported overdose education and nasal naloxone distribution (OEND) programs on rates of opioid related death from overdose and acute care utilization in Massachusetts. DESIGN Interrupted time series analysis of opioid related overdose death and acute care utilization rates from 2002 to 2009 comparing(More)
PURPOSE We examine reporting of nonfatal injury and illness reporting for the two most important sources of such data in the United States: workers' compensation data and the Bureau of Labor Statistics' (BLS) annual Survey of Occupational Injuries and Illnesses. METHODS We linked individual case records from establishments reporting to the BLS with(More)
The objective of this study was to determine the T1, T2 and secular-T2 relaxo-volumetric brain aging patterns using multispectral quantitative magnetic resonance imaging, both globally and regionally, and covering an age range approaching the full human lifespan. Fifty-one subjects (28 males, 23 females; age range: 0.5-87 years) were studied consisting of(More)
BACKGROUND In patients receiving oral anticoagulation, improved control can reduce adverse outcomes such as stroke and major hemorrhage. However, little is known about patient-level predictors of anticoagulation control. OBJECTIVES To identify patient-level predictors of oral anticoagulation control in the outpatient setting. PATIENTS/METHODS We studied(More)
OBJECTIVE Executive functioning has been repeatedly linked to the integrity of instrumental activities of daily living (IADL). The present study examined the association of multiple executive functioning elements (i.e., working memory, generation, inhibition, planning, and sequencing) to IADLs among an older adult cohort at risk for future cognitive and(More)
AIMS To test the feasibility of online alcohol screening and brief intervention (BI) by comparing (i) two approaches to inviting all students to be screened, and (ii) a minimal versus a more extensive BI. METHODS Freshmen students at one university were randomized to receive one of two types of email invitations to an online anonymous: (i) general health(More)
Abbreviated neuropsychological protocols are increasingly utilized secondary to time-constraints within research and healthcare settings, yet normative data for these abbreviated instruments are lacking. We present geriatric performances and normative data for the Boston Naming Test 30-item even version (BNT-30). Data were utilized from the BU-ADCC registry(More)
OBJECTIVE To characterize symptoms and signs of AL amyloidosis that may bring patients to the attention of rheumatologists, evaluate Ig V(L) gene usage in this subgroup of patients, and assess the impact of soft tissue and bone involvement and V(L) gene usage on survival. METHODS Clinical features of soft tissue and bone involvement were assessed in 191(More)
Overdose education and naloxone distribution (OEND) is an intervention that addresses overdose, but has not been studied among people who take methadone, a drug involved in increasing numbers of overdoses. This study describes the implementation of OEND among people taking methadone in the previous 30 days in various settings in Massachusetts. From 2008 to(More)
BACKGROUND A variety of statistical methods have been suggested to assess the degree and/or the location of spatial clustering of disease cases. However, there is relatively little in the literature devoted to comparison and critique of different methods. Most of the available comparative studies rely on simulated data rather than real data sets. METHODS(More)