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BACKGROUND In patients receiving oral anticoagulation, improved control can reduce adverse outcomes such as stroke and major hemorrhage. However, little is known about patient-level predictors of anticoagulation control. OBJECTIVES To identify patient-level predictors of oral anticoagulation control in the outpatient setting. PATIENTS/METHODS We studied(More)
PURPOSE We examine reporting of nonfatal injury and illness reporting for the two most important sources of such data in the United States: workers' compensation data and the Bureau of Labor Statistics' (BLS) annual Survey of Occupational Injuries and Illnesses. METHODS We linked individual case records from establishments reporting to the BLS with(More)
AIMS To test the feasibility of online alcohol screening and brief intervention (BI) by comparing (i) two approaches to inviting all students to be screened, and (ii) a minimal versus a more extensive BI. METHODS Freshmen students at one university were randomized to receive one of two types of email invitations to an online anonymous: (i) general health(More)
OBJECTIVE To evaluate the impact of state supported overdose education and nasal naloxone distribution (OEND) programs on rates of opioid related death from overdose and acute care utilization in Massachusetts. DESIGN Interrupted time series analysis of opioid related overdose death and acute care utilization rates from 2002 to 2009 comparing(More)
The objective of this study was to determine the T1, T2 and secular-T2 relaxo-volumetric brain aging patterns using multispectral quantitative magnetic resonance imaging, both globally and regionally, and covering an age range approaching the full human lifespan. Fifty-one subjects (28 males, 23 females; age range: 0.5-87 years) were studied consisting of(More)
OBJECTIVE To determine whether participants with mild cognitive impairment (MCI) differ from cognitively normal (NC) older adults on traditional and novel informant-based measures of activities of daily living (ADL) and to identify cognitive correlates of ADLs among participants with MCI. DESIGN Cross-sectional. SETTING University medical setting. (More)
Although the presence of abnormal late gadolinium enhancement (LGE) in cardiac amyloidosis has been well established, its prognostic implication and utility to identify cardiac involvement in patients with systemic amyloidosis is unknown. The aim of this study was to assess the diagnostic and prognostic significance of cardiovascular magnetic resonance(More)
OBJECTIVE The objective of our study was to compare the diagnostic accuracy of IV contrast-enhanced 64-MDCT with and without the use of oral contrast material in diagnosing appendicitis in patients with abdominal pain. MATERIALS AND METHODS We conducted a randomized trial of a convenience sample of adult patients presenting to an urban academic emergency(More)
OBJECTIVE To characterize symptoms and signs of AL amyloidosis that may bring patients to the attention of rheumatologists, evaluate Ig V(L) gene usage in this subgroup of patients, and assess the impact of soft tissue and bone involvement and V(L) gene usage on survival. METHODS Clinical features of soft tissue and bone involvement were assessed in 191(More)
OBJECTIVE Executive functioning has been repeatedly linked to the integrity of instrumental activities of daily living (IADL). The present study examined the association of multiple executive functioning elements (i.e., working memory, generation, inhibition, planning, and sequencing) to IADLs among an older adult cohort at risk for future cognitive and(More)