Aku Seppänen

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OBJECTIVE To improve walking and other aspects of physical function with a progressive 6-month exercise program in patients with multiple sclerosis (MS). METHODS MS patients with mild to moderate disability (Expanded Disability Status Scale scores 1.0 to 5.5) were randomly assigned to an exercise or control group. The intervention consisted of strength(More)
Cardiovascular autonomic nerve function and its relation to the clinical variables of untreated recent onset and levodopa-treated advanced disease parkinsonian patients were studied. Heart rate variations were diminished in both groups when compared with age-matched controls. An orthostatic blood pressure drop was found in both disease groups. The drop was(More)
The effect of gradually increasing COHb saturation on human visuoperceptual and psychomotor performance was studied in 22 nonsmokers and 22 smokers. Each subject performed two sessions in randomized order, one during air breathing and the other during CO breathing on two separate days. Testing and COHb saturation measurement were repeated six times during(More)