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PURPOSE Small cell neuroendocrine carcinoma of the prostate is likely to become increasingly common with recent advances in pharmacologic androgen suppression. Thus, developing molecular markers of small cell differentiation in prostate cancer will be important to guide the diagnosis and therapy of this aggressive tumor. EXPERIMENTAL DESIGN We examined(More)
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top(More)
BACKGROUND The association of murine asthma with adiposity may be mediated by adiponectin, an anti-inflammatory adipokine with reduced serum concentrations in obese subjects. A study was undertaken to examine whether the serum adiponectin concentration is associated with human asthma and whether it explains the association between adiposity and asthma,(More)
OBJECTIVE Widespread knowledge of cardiopulmonary resuscitation (CPR) is critical to improving survival in sudden cardiac death. We analyzed YouTube, an Internet video-site which is a growing source of healthcare information for source, content and quality of information about CPR. METHODS YouTube was queried using keywords "CPR", "Cardiopulmonary(More)
BACKGROUND We recently reported on preclinical and feasibility studies (Innovation, Development, Exploration, Assessment, Long-term study [IDEAL] phase 0-1) of the development of robotic kidney transplantation (RKT) with regional hypothermia. This paper presents the IDEAL phase 2a studies of technique development. OBJECTIVES To describe the technique of(More)
BACKGROUND The ongoing H1N1 influenza pandemic has created a significant amount of health concern. Adequate dissemination of correct information about H1N1 influenza could help in decreasing the disease spread and associated anxiety in the population. PURPOSE This study aims to examine the effective use of the popular Internet video site YouTube as an(More)
RATIONALE The developed world is currently facing an epidemic of obesity. With the increased prevalence of obesity has come the recognition that obesity is a risk factor for asthma. OBJECTIVES The purpose of this workshop was to bring together experts in the field of asthma, with experts in the field of obesity to review the current state-of-the-art(More)
BACKGROUND Leptin, a pro-inflammatory cytokine produced by adipose tissue, has previously been shown to be associated with asthma in children. We hypothesised that high serum leptin concentrations would also be associated with asthma in adults. METHODS The Third National Health and Nutrition Examination Survey is a cross sectional study that included(More)
OBJECTIVE To look into effective use of popular Internet site YouTube as an information source on kidney stone disease. Urolithiasis is among the most common urological conditions, accounting for significant morbidity, however adequate education regarding simple lifestyle modifications and early recognition of symptoms can reduce recurrence and visits to(More)
BACKGROUND Although long-chain ω-3 (n-3) PUFAs (LCω3PUFAs) have been linked to the prevention of some inflammatory disorders, little is known about the association between these fatty acids and incidence of asthma. OBJECTIVE The objective was to prospectively investigate the association between LCω3PUFAs and fish intake and incidence of asthma among(More)