Akshat Sharma

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The efficacy of prophylactic penicillin and of 14 valent pneumococcal vaccine in preventing pneumococcal infection in homozygous sickle cell (SS) disease was investigated in 242 children aged 6 months to 3 years at entry. In the first five years of the trial there were 11 pneumococcal infections in the pneumococcal vaccine treated group, 10 by serotypes(More)
Epstein-Barr virus (EBV) infection causes B cell lymphomas in humanized mouse models and contributes to a variety of different types of human lymphomas. T cells directed against viral antigens play a critical role in controlling EBV infection, and EBV-positive lymphomas are particularly common in immunocompromised hosts. We previously showed that EBV(More)
The cytokine IL-1β plays a central role in inflammatory responses that are initiated by microbial challenges, as well as in those that are due to endogenous processes (often called sterile inflammation). IL-1β secretion that occurs independently of microbial stimulation is typically associated with the presence of endogenous alarmins, such as extracellular(More)
OBJECTIVE Stosstherapy has been used since early 19th century for treating nutritional rickets. However, there are no clear cut guidelines for the biochemical monitoring of this treatment. Repeated blood tests at short intervals increase the cost of therapy and noncompliance. METHODS A prospective study was conducted on 191 cases of nutritional rickets(More)
Using a sensitive ELISA, specific serum and bile anti-Giardia IgM and IgA responses were studied in rats infected with two strains of Giardia duodenalis: a rat isolate which produces a chronic infection and a mouse isolate which produces a self-limiting infection. Paired samples of serum and bile were collected from groups of DA (RT1avl) rats at various(More)
Giardia isolated from mice and rats have been identified as Giardia duodenalis by morphological criteria. No differences in the electrophoretic mobilities of 28 enzymes were detected between the mouse and rat isolates or between these isolates and human and cat isolates. Infections with both rodent isolates have been studied in several strains of inbred(More)
Invariant natural killer T (iNKT) cells are innate T lymphocytes that promote host defense against a variety of microbial pathogens. Whether microbial ligands are required for their protective effects remains unclear. Here, we show that iNKT cells stimulate human-monocyte-derived dendritic cells (DCs) to produce inflammatory mediators in a manner that does(More)
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