Aknar Freire de Carvalho Calabrich

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While CBA/J mice fail to be permissive to Leishmania amazonensis-driven pathogenic processes, they heal easily following Leishmania major infection. The early-phase events are crucial to the outcome of Leishmania infection and it is known that macrophages (Mphi) are important in infection control. In the present study we investigated the role of Mphi in(More)
The use of adjuvant chemotherapy following resection for all patients with stage III colon cancer is now part of the standard of care around the world. Recent trials have led to changes in the standard regimens, which now include the use of oxaliplatin (Eloxatin) for most patients with stage III colon cancer. The addition of oxaliplatin has resulted in a(More)
Many breast cancer patients with HER2 overexpression do not respond to initial therapy with trastuzumab (Herceptin), and the vast majority of those who initially respond to the agent develop resistance to treatment within 1 year. This review will discuss several molecular mechanisms that can lead to the development of trastuzumab resistance, including loss(More)
In this case report, we describe a rare case of a 32-year-old man who presented a highly aggressive, fast growing anaplastic oligodendroglioma five years after being treated with whole brain radiotherapy for a CNS recurrence of a lymphoblastic lymphoma. Initially, the patient was submitted to a surgical intervention and partial tumor resection, which(More)
OBJECTIVE The aim of this study was to characterize and quantify metabolic acidosis that was caused by initial volume expansion during the reanimation of patients with severe sepsis and septic shock. METHODS A blood sample was drawn for physicochemical characterization of the patient's acid-base equilibrium both before and after volume expansion using 30(More)
Carcinoembriogenic antigen (CEA) is a serum marker commonly used as a clinical tool in the follow-up of patients with several types of tumor, particularly colorectal carcinoma. An elevation in CEA levels can precede clinical evidence of recurrence, but these levels can also increase in patients with nonmalignant pathologies. Nevertheless, an elevation in(More)
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