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Application of the histone deacetylase inhibitors for the treatment of endometriosis: histone modifications as pathogenesis and novel therapeutic target.
BACKGROUND Accumulating evidence suggests that various epigenetic aberrations play definite roles in the pathogenesis of endometriosis. We investigated the histone acetylation status in endometriosis… Expand
Aberrant Expression of Apoptosis-Related Molecules in Endometriosis
Endometriosis, a disease affecting 3% to 10% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue under the influence of estrogen. It is also becoming recognized… Expand
Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells.
Triptolide (TPL), a bioactive component of the Chinese medicinal herb Tripterygium wilfordii Hook F, induces apoptosis in some lines of human tumor cells. However, the effect of TPL on gynecologic… Expand
A case of benign metastasizing leiomyoma treated by surgical castration followed by an aromatase inhibitor, anastrozole
- K. Nasu, A. Tsuno, N. Takai, H. Narahara
- Archives of Gynecology and Obstetrics
- 1 February 2009
BackgroundBenign metastasizing leiomyoma (BML) is a rare disease most often located in the lungs of women with a history of surgery for benign leiomyoma of the uterus. Optimum therapy for BML, has… Expand
Involvement of resistance to apoptosis in the pathogenesis of endometriosis.
- K. Nasu, A. Yuge, A. Tsuno, M. Nishida, H. Narahara
- Histology and histopathology
- 1 September 2009
Endometriosis, a disease affecting 3-10% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue. Increasingly, endometriosis is also becoming recognized as a… Expand
Attachment to extracellular matrices is enhanced in human endometriotic stromal cells: a possible mechanism underlying the pathogenesis of endometriosis.
- M. Adachi, K. Nasu, A. Tsuno, A. Yuge, Y. Kawano, H. Narahara
- European journal of obstetrics, gynecology, and…
- 1 March 2011
OBJECTIVE Endometriosis is characterized by the ectopic growth of endometrial tissue. One of the first steps to the spread of endometriosis in the peritoneal cavity is the attachment of endometriotic… Expand
Synchronous ovarian endometrioid adenocarcinoma with a functioning stroma and endometrial endometrioid adenocarcinoma by different loss of heterozygosity findings
- N. Takai, K. Kai, A. Tsuno, K. Nasu, K. Kashima, H. Narahara
- Archives of Gynecology and Obstetrics
- 1 October 2011
PurposeMucinous epithelial ovarian tumors generally have estrogenic stroma, although the frequency of endometrioid adenocarcinoma with functioning stroma is very low. And while synchronous… Expand
Simvastatin inhibits the proliferation and the contractility of human endometriotic stromal cells: a promising agent for the treatment of endometriosis.
Simvastatin significantly inhibited the proliferation of endometriotic stromal cells, attenuated the collagen gel contraction mediated by these cells, and suppressed endometriotic stromal cell… Expand
Fasudil inhibits the proliferation and contractility and induces cell cycle arrest and apoptosis of human endometriotic stromal cells: a promising agent for the treatment of endometriosis.
- A. Tsuno, K. Nasu, +4 authors H. Narahara
- The Journal of clinical endocrinology and…
- 15 September 2011
CONTEXT During the development of endometriotic lesions, excess fibrosis may lead to scarring and to the alterations of tissue function that are the characteristic features of this disease. Enhanced… Expand
Mevalonate-Ras Homology (Rho)/Rho-Associated Coiled-Coil-Forming Protein Kinase (ROCK)-Mediated Signaling Pathway as a Therapeutic Target for the Treatment of Endometriosis-Associated Fibrosis
a disease affecting 3-10% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue. Histologically, this disease is characterized by endometrial gland and stroma… Expand