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Amyotrophic lateral sclerosis (ALS) is a late-onset, fatal disorder in which the motor neurons degenerate. The discovery of new drugs for treating ALS has been hampered by a lack of access to motor neurons from ALS patients and appropriate disease models. We generate motor neurons from induced pluripotent stem cells (iPSCs) from familial ALS patients, who(More)
  • Hongmei Lisa Li, Naoko Fujimoto, Noriko Sasakawa, Saya Shirai, Tokiko Ohkame, Tetsushi Sakuma +7 others
  • 2015
Duchenne muscular dystrophy (DMD) is a severe muscle-degenerative disease caused by a mutation in the dystrophin gene. Genetic correction of patient-derived induced pluripotent stem cells (iPSCs) by TALENs or CRISPR-Cas9 holds promise for DMD gene therapy; however, the safety of such nuclease treatment must be determined. Using a unique k-mer database, we(More)
We assessed the cerebral hemoglobin oxygenation response in the left frontal area in 62 schizophrenia patients and 31 healthy subjects during a verbal fluency test (VF) and letter number span test (LN) measured by near-infrared spectroscopy (NIRS). Oxygenated hemoglobin (oxyHb) increased during VF and LN in both groups. Schizophrenia patients showed lower(More)
Activation-induced cytidine deminase (Aid), a unique enzyme that deaminates cytosine in DNA, shuttles between the nucleus and the cytoplasm. A recent study proposed a novel function of Aid in active DNA demethylation via deamination of 5-hydroxymethylcytosine, which is converted from 5-methylcytosine by the Ten-eleven translocation (Tet) family of enzymes.(More)
A learning system composed of linear control modules, reinforcement learning modules and selection modules (a hybrid reinforcement learning system) is proposed for the fast learning of real-world control problems. The selection modules choose one appropriate control module dependent on the state. This hybrid learning system was applied to the control of a(More)
OBJECTIVE Attention to risk of antipsychotics for older patients with delirium has been paid. A clinical question was whether risk of antipsychotics for older patients with delirium would exceed efficacy of those even in the general hospital setting. METHODS A prospective observational study proceeded over a 1-year period at 33 general hospitals, where at(More)
—IP mobility is the technology that realizes a continuous communication even when communicating wireless nodes switch access networks. NTMobile (Network Traversal with Mobility) is a new type of IP mobility technology for the IPv4 and IPv6 networks. NTMobile nodes can also achieve IP mobility in global IP networks as well as in private IP networks by(More)
Researches on the wireless mesh network in which access points (APs) of a wireless LAN are connected by an ad-hoc networks are recently drawing much attention. In the wireless mesh network, APs can be set up freely and its areas can be expanded easily. For the wireless mesh network, methods of utilizing multiple gateways (GWs) at the time of making a(More)