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  • Hiroaki Shimokawa, Hiromitsu Yasutake, +8 authors Akira Takeshita
  • Medicine
  • Journal of cardiovascular pharmacology
  • 1996 (First Publication: 1 November 1996)
  • Endothelium-dependent relaxations are achieved by a combination of endothelium-derived prostacyclin (PGI2), nitric oxide (NO), and endothelium-derived hyperpolarizing factor (EDHF). However, itExpand
  • Midoriko Higashi, Hiroaki Shimokawa, +6 authors Akira Takeshita
  • Medicine, Biology
  • Circulation research
  • 2003 (First Publication: 17 October 2003)
  • Abstract— Intracellular signaling pathway mediated by small GTPase Rho and its effector Rho-kinase plays an important role in regulation of vascular smooth muscle contraction and other cellularExpand
  • Shunji Hayashidani, Hiroyuki Tsutsui, +6 authors Akira Takeshita
  • Medicine
  • Circulation
  • 2003 (First Publication: 31 March 2002)
  • Background—Increased expression of monocyte chemoattractant protein-1 (MCP-1) has recently been described in clinical and experimental failing heart. However, its pathophysiological significance inExpand