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To understand the mechanism of transcriptional regulation, it is essential to identify and characterize the promoter, which is located proximal to the mRNA start site. To identify the promoters from the large volumes of genomic sequences, we used mRNA start sites determined by a large-scale sequencing of the cDNA libraries constructed by the "oligo-capping"(More)
A solid-phase method for solving the Hamiltonian path problem (HPP) is described. The method employs only fast and simple DNA operations amenable to full automation. Single-stranded DNA molecules representing paths with no city visited twice are synthesized city-by-city from the start city on the surface of a solid support. The solution can thus be found in(More)