Akira Shimada

Yusuke Kabeya8
Masuomi Tomita8
Taro Maruyama7
8Yusuke Kabeya
8Masuomi Tomita
7Taro Maruyama
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OBJECTIVE Fulminant type 1 diabetes is characterized by the rapid onset of severe hyperglycemia and ketoacidosis, with subsequent poor prognosis of diabetes complications. Causative mechanisms for accelerated beta-cell failure are unclear. RESEARCH DESIGN AND METHODS Subjects comprised three autopsied patients who died from diabetic ketoacidosis within(More)
  • Takuya Awata, Hisakuni Yamashita, Susumu Kurihara, Tomoko Morita-Ohkubo, Yumi Miyashita, Shigehiro Katayama +10 others
  • 2015
There are errors in Tables 2 and S2. Please see the corrected tables below. Copyright: © 2015 Awata et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
  • Kaoru Aida, Yoriko Nishida, Shoichiro Tanaka, Taro Maruyama, Akira Shimada, Takuya Awata +12 others
  • 2011
OBJECTIVE The contribution of innate immunity responsible for aggressive β-cell destruction in human fulminant type 1 diabetes is unclear. RESEARCH DESIGN AND METHODS Islet cell expression of Toll-like receptors (TLRs), cytoplasmic retinoic acid-inducible gene I (RIG-I)-like receptors, downstream innate immune markers, adaptive immune mediators, and(More)
BACKGROUND The association between diabetes and paranasal sinus disease has not been thoroughly investigated. METHODS We cross-sectionally investigated the association between diabetes and the presence of paranasal sinus disease, which was confirmed by a head MRI scan in 1350 adults who underwent a health screening program focusing on brain diseases and(More)
  • Takuya Awata, Hisakuni Yamashita, Susumu Kurihara, Tomoko Morita-Ohkubo, Yumi Miyashita, Shigehiro Katayama +10 others
  • 2014
Elucidation of the genetic susceptibility factors for diabetic retinopathy (DR) is important to gain insight into the pathogenesis of DR, and may help to define genetic risk factors for this condition. In the present study, we conducted a three-stage genome-wide association study (GWAS) to identify DR susceptibility loci in Japanese patients, which(More)
Introduction. There is no report about risk factors for renal deterioration according to the clinical stage, divided by the estimated glomerular filtration rate (eGFR) in type 2 diabetes. Materials and Methods. We evaluated the factors correlated with the annual eGFR decline in 1303 subjects with type 2 diabetes whose eGFR was ≥30 mL/min/1.73 m(2). eGFR(More)
OBJECTIVE To determine whether development of insulin requirement in patients with latent autoimmune diabetes in adults (LADA) is accompanied with the emergence of a type 1 diabetes-like autoimmune response. RESEARCH DESIGN AND METHODS We correlated beta-cell-specific autoimmunity reflected in autoantibodies to the 65-kDa isoform of GAD (GAD65) with(More)
AIM To determine the diabetic foot ulcer incidence and examine its association with microangiopathy complications, including diabetic retinopathy (DR) and albuminuria (Alb), in type 2 diabetes patients. METHODS This was a retrospective cohort study of 1,305 patients with type 2 diabetes who were assigned to the following groups: Category 1,(More)
Abbreviations AT1D Acute-onset type 1 diabetes DEHD Ductal epithelial hyperplasia/dysplasia JDS Japan Diabetes Society SPIDDM Slowly progressive insulin-dependent diabetes mellitus To the Editor: The report by Campbell-Thompson and colleagues [1], providing evidence that pancreatic weight is reduced irrespective of duration in type 1 diabetic donors,(More)