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Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: novel, highly potent and orally efficacious squalene synthase inhibitors.
- Masanori Ichikawa, A. Yokomizo, +5 authors Akira Kanda
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 September 2011
We have recently reported the discovery of the new benzhydrol template, which has a highly potent inhibitory activity for squalene synthase, as typified by compound 1 (SSI IC(50)=0.85 nM). However,… Expand
Discovery of DF-461, a Potent Squalene Synthase Inhibitor.
- Masanori Ichikawa, Masami Ohtsuka, +8 authors K. Sugita
- Medicine
- ACS medicinal chemistry letters
- 6 September 2013
We report the development of a new trifluoromethyltriazolobenzoxazepine series of squalene synthase inhibitors. Structure-activity studies and pharmacokinetics optimization on this series led to the… Expand
Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors.
- Masanori Ichikawa, A. Yokomizo, +6 authors K. Sugita
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 March 2011
To obtain small and efficient squalene synthase inhibitors, a flexible 2-aminobenzhydrol open form structure was designed and showed potent inhibitory activity comparable to 4,1-benzoxazepin… Expand
Discovery of novel tricyclic compounds as squalene synthase inhibitors.
- Masanori Ichikawa, Masami Ohtsuka, +7 authors Akira Kanda
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 May 2012
In the present article, we have reported the design, synthesis, and identification of highly potent benzhydrol derivatives as squalene synthase inhibitors (compound 1). Unfortunately, the in vivo… Expand
Corrigendum to “Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors” [Bioorg. Med. Chem. 19 (2011) 1930–1949]
- Masanori Ichikawa, A. Yokomizo, +6 authors K. Sugita
- Chemistry
- 1 June 2014
Th-P16:323 Lipid-lowering properties of squalene synthase inhibitor; effects on HDL cholesterol formation and triglyceride biosynthesis
- Akira Kanda, K. Terayama, +4 authors K. Nishida
- Medicine
- 2006
Correction to “Discovery of DF-461, a Potent Squalene Synthase Inhibitor”
- Masanori Ichikawa, Masami Ohtsuka, +8 authors K. Sugita
- Biology
- 12 June 2014
According to the recent reconsideration and re-evaluation of every author’s contribution of this work, all of authors have reached the final conclusion that we should rearrange the order of the… Expand