Akira Higuchi

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X-Linked thrombocytopenia (XLT) is characterized by congenital thrombocytopenia with small platelets and absence of immunodeficiency; XLT is an allelic variant of Wiskott-Aldrich syndrome (WAS). Both entities are caused by mutations in the same gene. This study presents the case of an 8-year-old boy with XLT. He developed immunoglobulin A (IgA) nephropathy(More)
We describe an 8-year-old boy who presented with steroid-resistant nephrotic syndrome (SRNS) associated with X-linked ichthyosis (XLI). At birth, the patient exhibited scaly skin, cryptorchidism, and steroid sulfatase (STS) deficiency. DNA analysis showed deletion of exons 1–10 of the STS gene. Proteinuria developed at 6 years and was resistant to steroid(More)
Polarimetric measurements of scattering coefficient σ of a bare soil were performed changing a roughness of a soil surface and a soil moisture content using the 35 GHz polarimetric scatterometer. At Ka band, a few experimental results of σ data are available. One of the purpose of this experiment is to obtain the surface backscattering characteristics to(More)
A robotic system has been developed to be used for macromolecular crystallization and observation in typical university laboratories with a research focus on protein crystallography. The system consists of three major parts: a dispenser unit, a storage unit and an observation unit. This system is designed to automatically perform all of the processes(More)
The system of all the closure operators on a set V forms a lattice. This lattice is isomorphic to the lattice of all the Moore families of subsets of V. This paper describes basic properties of these lattices, and gives a method to find all the members of these lattices. 1. Closure operators A map C : ~ ( V ) ~ ( V ) is called a closure operator on V if it(More)
The immunofluorescent localization of glomerular basement membrane (GBM) antigens was examined in 52 specimens from normal kidneys and in various renal diseases using antisera to human GBM HGBM), IV type collagen (IV Col) and P3 antigen, a rat nephritogen. Anti-HGBM serum normally stained the GBM and the mesangium in a restrictive pattern, anti-IV Col serum(More)
The purpose of this study was to investigate the anti-arthritic effects of synthesized chondroitin sulfate E hexasaccharide (sCSE-6, CAS 866407-73-0), using a type II collagen-induced arthritis model in mice. sCSE-6 was administered subcutaneously on a daily basis to type II collagen (CII)-sensitized mice from day 0 to day 55. The severity of arthritis, as(More)
Life-threatening cardiovascular anomalies require surgery for structural repair with cardiovascular patches. The biomaterial patch, derived from Bombyx mori silk fibroin (SF), is used as an alternative material due to its excellent tissue affinity and biocompatibility. However, SF lacks the elastomeric characteristics required for a cardiovascular patch. In(More)