Akira Fukushima

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In a previous paper, we presented a practical in vivo micronucleus (MN) test that used rat skin as the target organ. To evaluate the test, as well as to determine the reproducibility and applicability of the method to mice, we used it to test the effect of five skin carcinogens (N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG),(More)
A long-term investigation on the water quality and hydrology was carried out for 8 years and 7 months (from October 1991 to April 2000) in a paddy field watershed using a circular irrigation system. The annual amount of rainfall ranged from 1270 to 2226 mm and it was found that the amount of irrigation water tended to decrease as rainfall increased.(More)
The standard in vivo micronucleus (MN) test detects clastogenicity in hematopoietic cells and is not suitable for detecting chemicals that target the skin. Previously, we have developed an in vivo rodent skin MN test that is simple to perform and can be applied to several laboratory animals, including the hairless mouse-a species whose use simplifies the(More)
In our previous study, we identified a QTL for cold tolerance at the booting stage of ‘Ukei840’, the cold tolerance of which is derived from one of the most tolerant cultivars, ‘Lijiangxintuanheigu’, in Yunnan province of China, in a 1.2-Mb region between RM7000 and RM3719 markers on chromosome 3. In the present study, we delimited the previously identified(More)
We developed a method to assess the similarity of pharmacokinetic data between ethnically different populations. An evaluation of confidence intervals for the mean difference in pharmacokinetic parameters, such as area under the concentration-versus-time curve (AUC), between populations is often used. We propose the use of the overlap coefficient (OC),(More)
The 3D tissue construction is one of the important issues for regenerative medicine. Recently, several studies have been reported, related to realize small size of 3D tissue like cells based structure in vitro. However, large size functional 3D tissue has not been achieved due to the size causing difficulties. In large size cells based structure, supplying(More)
Cell tissue construction is one of the important issues for tissue engineering, which is a key-technology in regenerative medicine. Recently, several studies have reported, the in vitro fabrication of simple cell tissues. However, organs are made of some kinds of cells and they are complex tissues. Therefore, a technology to reproduce the complex structure(More)