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In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5'-phosphate supplementation.

• Xinghua Sun, Zhijian Yang, +10 authors Robert M Hoffman
• Cancer research
• 2003

Recombinant methioninase (rMETase) is an enzyme active in preclinical mouse models of human cancer. The efficacy of rMETase is due to depletion of plasma methionine, an amino acid for which tumors… (More)

Stress-induced factor involved in flower formation of Lemna is an alpha-ketol derivative of linolenic acid.

• Mineyuki Yokoyama, Shizuko Yamaguchi, +7 authors Akio Takimoto
• Plant & cell physiology
• 2000

A stress-induced substance(s) (factor C) incubated with norepinephrine (NE) has strong flower-inducing activity in Lemna paucicostata. We isolated an essential component (FIF) of factor C, and… (More)

Quantitative glycomics of human whole serum glycoproteins based on the standardized protocol for liberating N-glycans.

• Yoko Kita, Yoshiaki Miura, +5 authors Shin-Ichiro Nishimura
• Molecular & cellular proteomics : MCP
• 2007

Global glycomics of human whole serum glycoproteins appears to be an innovative and comprehensive approach to identify surrogate non-invasive biomarkers for various diseases. Despite the fact that… (More)

Denitrification, a novel type of respiratory metabolism in fungal mitochondrion.

• Mikirou Kobayashi, Yukinori Matsuo, Akio Takimoto, Shingo Suzuki, Fumiaki Maruo, Hirofumi Shoun
• The Journal of biological chemistry
• 1996

Subcellular localization and coupling to ATP synthesis were investigated with respect to the denitrifying systems of two fungi, Fusarium oxysporum and Cylindrocarpon tonkinense. Dissimilatory nitrate… (More)

Functional analysis of recombinant pancreatic secretory trypsin inhibitor protein with amino-acid substitution

• Kinuko Kuwata, Masahiko Hirota, +8 authors Michio Ogawa
• Journal of Gastroenterology
• 2002

We hypothesized that mutation of the pancreatic secretory trypsin inhibitor (PSTI) gene may promote a predisposition to pancreatitis, possibly by reducing the inhibition of trypsin activity. Based on… (More)

Assay method for antitumor L-methionine gamma-lyase: comprehensive kinetic analysis of the complex reaction with L-methionine.

• Tomoaki Takakura, Kenji Mitsushima, +5 authors Akio Takimoto
• Analytical biochemistry
• 2004

L-Methionine gamma-lyase (EC 4.4.1.11) is a pyridoxal 5'-phosphate-dependent multifunctional enzyme. Measuring the initial velocity of alpha-ketobutyrate production by alpha,gamma-elimination of… (More)

Structure of the antitumour enzyme L-methionine gamma-lyase from Pseudomonas putida at 1.8 A resolution.

• Daizou Kudou, Shintaro Misaki, +8 authors Kenji Inagaki
• Journal of biochemistry
• 2007

l-Methionine gamma-lyase (EC 4.4.1.11, MGL_Pp) from Pseudomonas putida is a multifunctional enzyme, which belongs to the gamma-family of pyridoxal-5'-phosphate (PLP) dependent enzymes. In this… (More)

High-level expression and bulk crystallization of recombinant l-methionine γ-lyase, an anticancer agent

• Tomoaki Takakura, Takaomi Ito, +7 authors Akio Takimoto
• Applied Microbiology and Biotechnology
• 2005

l-Methionine γ-lyase is a pyridoxal 5′-phosphate-dependent enzyme which has tumor selective anticancer activity. An efficient production process for the recombinant enzyme was constructed by using… (More)

Chemoenzymatic synthesis of glycosylated glucagon-like peptide 1: effect of glycosylation on proteolytic resistance and in vivo blood glucose-lowering activity.

• Taichi Ueda, Kazuyoshi Tomita, +14 authors Hirosato Kondo
• Journal of the American Chemical Society
• 2009

Glucagon-like peptide 1 (7-36) amide (GLP-1) has been attracting considerable attention as a therapeutic agent for the treatment of type 2 diabetes. In this study, we applied a glycoengineering… (More)

Identification of a component that induces flowering of Lemna among the reaction products of alpha-ketol linolenic acid (FIF) and norepinephrine.

• Shizuko Yamaguchi, Mineyuki Yokoyama, Toshii Iida, Masahiko Okai, Osamu Tanaka, Akio Takimoto
• Plant & cell physiology
• 2001

A stress-induced fatty acid [FIF; 9-hydroxy-10-oxo-12(Z),15(Z)-octadecadienoic acid] incubated with (-)-norepinephrine (NE) strongly induces flower formation in Lemna paucicostata [Yokoyama et al.… (More)

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