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Although several studies have suggested that insulin-secreting cells can be generated in vitro from cells residing in adult exocrine pancreas, neither the origin of these cells nor their precise… (More)
We recently found that pancreatic acinar cells isolated from normal adult mouse can transdifferentiate into insulin-secreting cells in vitro. Using two different animal models of type 1 diabetes, we… (More)
Although pancreatic exocrine acinar cells have the potential to transdifferentiate into pancreatic endocrine cells, the mechanisms are poorly understood. Here we report that intracellular signaling… (More)
NeuroD is a transcriptional factor critical in differentiation of neuronal cells, enteroendocrine cells, and pancreatic endocrine cells. However, little is known of its roles in cellular functions.… (More)