Akila Subasinghe Arachchige

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The study of human metaphase chromosomes is an important aspect in clinical diagnosis of genetic disorders. Although many image processing techniques have been developed for chromosomal karyotyping to assist in laboratory diagnosis, they fail to provide reliable results in segmenting and extracting the centerline of chromosomes due to their shape(More)
Accurate detection of the human metaphase chromosome centromere is an important step in many chromosome analysis and medical diagnosis algorithms. The centromere location can be utilized to derive information such as the chromosome type, polarity assignment, etc. Methods available in the literature yield unreliable results mainly due to high variability of(More)
Centromere localization in human metaphase chromosomes is an essential task in many cytogenetic diagnosis procedures. The centromere location can be utilized to derive information such as the chromosome type, polarity assignment etc. Methods available in literature yield unreliable results mainly due to high variability of morphology in metaphase(More)
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