Akiko Uchiyama

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SMG1, a PI3K-related kinase, plays a critical role in nonsense-mediated mRNA decay (NMD) in mammals. SMG1-mediated phosphorylation of the UPF1 helicase is an essential step during NMD initiation. Both SMG1 and UPF1 are presumably activated by UPF2, but this regulation is incompletely understood. Here we reveal that SMG1C (a complex containing SMG1, SMG8,(More)
PURPOSE This study aimed to investigate how the cross-sectional areas (CSA) of the quadriceps femoris (QF)3, hamstrings (Ham), and psoas major (PM) in junior sprinters are related to mean running velocity (MV100m) calculated from official records of 100-m races. METHODS In 44 sprinters (22 boys and 22 girls) aged 14-17 yr, cross-sectional images were(More)
This study investigated the event-related differences in the cross-sectional areas (CSAs) and torque generation capabilities of the quadriceps femoris (QF) and hamstrings (HAM) in male high school athletes. Subjects were soccer players (n=32), volleyball players (21), rowers (29), karate athletes (18), sumo wrestlers (15), sprinters (22), throwers (16), and(More)
Nonsense-mediated mRNA decay (NMD) is an mRNA degradation pathway that regulates gene expression and mRNA quality. A complex network of macromolecular interactions regulates NMD initiation, which is only partially understood. According to prevailing models, NMD begins by the assembly of the SURF (SMG1-UPF1-eRF1-eRF3) complex at the ribosome, followed by(More)
Cooperative assemblies of transcription factors (TFs) on target gene enhancers coordinate cell proliferation, fate specification, and differentiation through precise and complicated transcriptional mechanisms. Chemical modifications, such as phosphorylation, of TFs induced by cell signaling further modulate the dynamic cooperativity of TFs. In this study,(More)
Rehabilitation aims to provide patients and their supporters with the knowledge, skills and support necessary to maintain their autonomy, minimize disability and maximize the level of participation of individual. This may be the case in Parkinson's disease (PD) patients. However, to our knowledge, previous papers concerning rehabilitation for PD patients(More)
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