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Glycoside Hydrolase Family 89 α-N-acetylglucosaminidase from Clostridium perfringens Specifically Acts on GlcNAcα1,4Galβ1R at the Non-reducing Terminus of O-Glycans in Gastric Mucin*
In mammals, α-linked GlcNAc is primarily found in heparan sulfate/heparin and gastric gland mucous cell type mucin. α-N-Acetylglucosaminidases (αGNases) belonging to glycoside hydrolase family 89 areExpand
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Efficient delivery of siRNA using dendritic poly(L-lysine) for loss-of-function analysis.
RNA interference (RNAi) is a valuable tool for the validation of gene identification and functional genomics. Previously, it was reported that 6th generation dendritic poly(L-lysine) (KG6)Expand
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Synthesis of Disialyl Lewis a (Lea) Structure in Colon Cancer Cell Lines by a Sialyltransferase, ST6GalNAc VI, Responsible for the Synthesis of α-Series Gangliosides*
Biosynthesis of disialyl Lewis a (Lea) was analyzed using previously cloned ST6GalNAc V and ST6GalNAc VI, which were responsible for the synthesis of α-series gangliosides. AmongExpand
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pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen.
In order to analyze the mechanisms for cancer metastasis, high metastatic sublines (H7-A, H7-Lu, H7-O, C4-sc, and C4-ly) were obtained by repeated injection of mouse Lewis lung cancer sublines H7 andExpand
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A New Type of Artificial Glycoconjugate Polymer: A Convenient Synthesis and Its Interaction with Lectins
A convenient synthetic route to a new type of artificial glycoconjugate polymer has been designed to develop biomedical materials using oligosaccharide moieties as recognition signals. An aminoExpand
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Membrane-associated Activation of Cholesterol α-Glucosyltransferase, an Enzyme Responsible for Biosynthesis of Cholesteryl-α-d-Glucopyranoside in Helicobacter pylori Critical for Its Survival
Helicobacter pylori (H. pylori) is the causative pathogen underlying gastric diseases such as chronic gastritis and gastric cancer. Previously, the authors revealed that α1,4-linkedExpand
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Expression and roles of a xenopus head-forming gene homologue in human cancer cell lines.
Molecular mechanisms for both morphogenesis and carcinogenesis have frequently overlapped, and similar signaling pathways are often involved in these processes. Yamamoto et al. identified a novelExpand
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Simple synthesis of sialyllactose-carrying polystyrene and its binding with influenza virus
Glycoconjugate polystyrenes bearing sialyllactose moieties were prepared via a simple method from a mixture of α2-6 and α2-3 linked sialyllactose isomers of bovine milk origin. The reducing end ofExpand
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Trimeric Tn Antigen on Syndecan 1 Produced by ppGalNAc-T13 Enhances Cancer Metastasis via a Complex Formation with Integrin α5β1 and Matrix Metalloproteinase 9*
Background: ppGalNAc-T13 is up-regulated in high metastatic murine lung cancer cell lines. Results: Trimeric Tn on Syndecan 1 forms a complex with integrin α5β1 and MMP-9, leading to cell adhesionExpand
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