Akiko Shimada

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This phase II study was conducted to investigate the efficacy and safety of irinotecan (CPT-11) and ifosfamide as second-line chemotherapy for relapsed small cell lung cancer (SCLC). Eligibility criteria included histologically or cytologically confirmed SCLC, prior chemotherapy including platinum + etoposide, and measurable or evaluable disease. CPT-11 (80(More)
OBJECTIVES/HYPOTHESIS Although uvulopalatopharyngoplasty (UPPP) is an attractive surgical treatment for obstructive sleep apnea (OSA), the unpredictable outcome limits application of the procedure. Since UPPP corrects only retropalatal airway (RP) patency, we hypothesized that response to UPPP is determined by collapsibility of the retroglossal airway (RG),(More)
A single intake of monosodium glutamate (MSG) may cause headache and increased muscle sensitivity. We conducted a double-blinded, placebo-controlled, crossover study to examine the effect of repeated MSG intake on spontaneous pain, mechanical sensitivity of masticatory muscles, side effects, and blood pressure. Fourteen healthy subjects participated in 5(More)
Collapsibility of the active pharynx, where active contraction of the upper airway muscles is evident, was previously reported to be higher in children with obstructive sleep apnea (OSA) than in those with primary snoring during sleep. Contribution of neuromuscular and anatomic factors to the increased collapsibility, however, was not estimated. We(More)
The aim of this study is to evaluate organ doses in infant CT examinations with multi-detector row CT scanners. Radiation doses were measured with radiophotoluminescence glass dosemeters set in various organ positions within a 1-y-old child anthropomorphic phantom and organ doses were evaluated from the measurement values. Doses for tissues or organs within(More)
Eccentric jaw exercises has been known to cause muscle soreness but no studies have so far examined to what extent temporal summation mechanisms within the exercised muscles are changed. The purpose of the present study was to investigate the effects of an eccentric biting exercise on the temporal summation, mechanical pressure sensitivity and jaw muscle(More)
Knowledge about how Temporomandibular Disorder (TMD) pain patients regulate masticatory function is still unclear. To investigate the effect of experimental jaw muscle pain as well as texture and size of food on mastication, twelve healthy participants (30.6±7.5 years old) participated in this study. Experimental pain was induced by an infusion of 0.5 M(More)
Hepatic hydrothorax is defined as the presence of a significant pleural effusion that develops in a patient with cirrhosis of the liver who does not have an underlying cardiac or pulmonary disease. There have been few published case reports dealing with hepatic hydrothorax treated surgically. Recently, we treated a patient with refractory hepatic(More)
OBJECTIVES/HYPOTHESIS Uvulopalatopharyngoplasty improves sleep-disordered breathing, particularly in patients with sleep-disordered breathing with abnormally high collapsible airway exclusively at the retropalatal airway, as was previously reported. The present study examined the direct and long-term effects of uvulopalatopharyngoplasty on retropalatal(More)
The nocturnal oxygenation of 45 patients with OSAS who had UPPP at our hospital were evaluated by pulse oximetry before and after surgery and at the time more than one year after UPPP. "Successful case" is defined as the case that showed more than 50% reduced oxygen desaturation index(ODI) after UPPP. Twenty seven cases including 15 severe cases(ODI > or =(More)