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BACKGROUND AND AIM Chronic hepatitis C virus (HCV) infection is a well known risk factor for hepatocellular carcinoma (HCC). The aim of this study is to elucidate the genetic risk of development and recurrence of HCC in patients with HCV. METHODS A total of 468 patients with HCV, including 265 with HCC were enrolled. We genotyped 88 single nucleotide(More)
To assess the potential volume of a glacial lake outburst flood (GLOF) more precisely than in previous studies, we analyze ground survey data and remote-sensing digital elevation models (DEMs) around glacial lakes in the Lunana region, Bhutan. Based on a DEM generated from differential GPS ground surveys, we first evaluate the relative accuracies of DEMs(More)
We investigated growth characteristics ofEuptelea polyandra Sieb. et Zucc. (Eupteleaceae), a Japanese endemic deciduous tree species growing on unstable ground such as that of very steep slopes with thin soil.Euptelea polyandra began to sprout at the juvenile stage and had a multiple-stemmed tree form. There was a positive correlation between diameter of(More)
Condensin and cohesin are chromosomal protein complexes required for chromosome condensation and sister chromatid cohesion, respectively. They commonly contain the SMC (structural maintenance of chromosomes) subunits consisting of a long coiled-coil with the terminal globular domains and the central hinge. Condensin and cohesin holo-complexes contain three(More)
Purpose: Aims of the study are to narrow-down the hotspot region on 10q21 defined by previous genome-wide loss of heterozygosity (LOH) analysis in head and neck squamous cell carcinomas (HNSCC) and to define candidate tumor suppressor genes (TSG) concerned with 10q21. Materials and methods: LOH analysis was carried out with ten polymorphic microsatellite(More)
Ciliary beat frequency (CBF) was measured in slice preparations of the Fallopian tube fimbria, using videomicroscopy with a high-speed (500 Hz) camera in guinea pigs that were treated with β-oestradiol benzoate (βE2B) and medroxy progesterone (mPRG). In non-ovulating guinea pigs at 4 weeks of age, the CBF of the fimbria was high (17.8 Hz). In sexually(More)
Reactive oxygen species (ROS) are potent oxidants that attack chromosomal DNA and free nucleotides, leading to oxidative DNA damage that causes genetic alterations. To avoid the ROS-mediated mutagenesis, cells have elaborate mechanisms including powerful antioxidant components and repair pathways that eliminate oxidative DNA damage. Because of the effective(More)
Based on the general tendency for females of dioecious plants to pay higher reproductive cost than males, it has been predicted that females should have much more reduced reproductive outputs and diminished vegetative production than males in energy-limited habitats. Nevertheless, this prediction has rarely been directly investigated. We investigated(More)
Head and neck squamous cell carcinoma (HNSCC) is a frequent malignancy with a poor survival rate. Identifying the tumor suppressor gene (TSG) loci by genomic studies is an important step to uncover the molecular mechanisms involved in HNSCC pathogenesis. We therefore performed comprehensive analyses on loss of heterozygosity (LOH) using a genome-wide panel(More)